Drugs for Antifungals

Question 1

Amphotericin B

Answer 1

Comes in regular or liposomal
Big note: CI in cardiopulmonary arrest
Can Cause: fever, chills, headache, malaise, rigors hypokalemia, hypomagnesimia, and nephrotoxic
ONLY COMPATIABLE WITH D5W

Question 2

Flucytosine

Answer 2

Myelosupression

Question 3

Azole Antifungals

Answer 3

Fluconazole, Voriconazole, Posaconazole

Posaconazole needs to be taken with food

Question 4

Fluconazole

Answer 4

Vagininal Candidiasis 150 mg po once
IV ratio 1:1
Remember increases LFTS and QT prolongation. Renally cleared so dose adjust except for Keto

Question 5

Echinocandins

Answer 5

Capsofungin and Micafungin
Dosing for Micafungin
Candidemia: 100 mg IV d
Esophageal Candidiasis: 150 mg IV d
All cause Histamine mediated sxs

Question 6

Nystatin

Answer 6

Oral suspension needs to be shaken well

Swish in the mouth for as much as possible then swallow

Question 7

Terbinafine

Answer 7

Oral terbinafine are hepatotoxic

Can take several months to see results.

Question 8

Candida Albicans Treatment

Answer 8

Mild: Topical antifungals

Moderate to severe or HIV+: Fluconazole

Question 9

Candida Albicans Esophogeal infection

Answer 9

Fluconazole

Question 10

Candida Krusei

Answer 10

Echinocandin or AMPB

Question 11

Aspergillus

Answer 11

Voriconazole or AMPB,

Question 12

Cryptococcus Neoformans

Answer 12

AMPB+Flucytosine or High dose Fluconazole+Flucytosine

Question 13

Dermatophytes

Answer 13

Terbinafine, itraconazole or Fluconazole