Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHCOL 401 > Drugs (final) > Flashcards

Drugs (final) Flashcards

1
Q

Bromocriptine

A

Class: Dopamine agonist
TX: GH excess

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Octreotide

A

Class: Somatostatin analog *more specific than GH
TX: GH excess, with less SE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Pegvisomant

A

Class: GH receptor antagonist
MOA: binds and prevents GH action
TX: GH excess

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Sermorelin

A

Class: synthetic GHRH *not as effective as GH
TX: GH deficiency, ineffective if deficiency is d/t pituitary production defect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Recombinant IGF-1

A

TX: GH deficiency, for patients with GH receptor mutation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

GH

A

MOA: Activate JAK/STAT signaling
TX: GH deficiency, where no growth by age 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Vasopressin

A

MOA: conserve body water by reducing urine output by increasing AQP2 in lumen
TX: Neurogenic diabetes, acute bleeding, CPR, vasodilatory shock

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Desmopressin

A

MOA: Boosts factor VIII concentrations, replacement for vasopressin
TX: Neurogenic diabetes, bedwetting, mild-moderate hemophilia
AVOID in conditions aggravated by water retention, cardiac insufficiency, CF, vascular disease, renal impairment, pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

NSAIDs

A

MOA: Block prostaglandin synthesis in kidneys to enhance vasopressin action

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Lithium

A

MOA: Antagonizes effect of vasopressin
TX: Used to treat CHF, edema, SIADH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Demeclocycline

A

MOA: Antagonizes vasopressin and actions downstream of V2R
TX: Used to treat CHF, edema, SIADH, and hyponatremia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Conivaptan

A

Class: V1a/V2R antagonist
TX: hyponatremia associated with SIADH, edema (CHF, cirrhosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Tolvaptan, Lixivaptan

A

Class: V2R specific antagonist
TX: hyponatremia associated with SIADH, edema (CHF, cirrhosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Synthetic oxytocin analogs

A

MOA: Couples to Gq/IP3 production, which leads to increase of intracellular Ca2+ that leads to smooth muscle contraction
TX: Induce labor
Advantage: fast acting (2-3min when IM), generally no SE
Disadvantage: more expensive than ergometrine, IM/IV only, not heat stable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Ergometrine

A

MOA: Couples to Gq/IP3 production, which leads to increase of intracellular Ca2+ that leads to smooth muscle contraction
TX: facilitation of placenta and reduce blood flow
Advantage: inexpensive, effect for 2-4hrs
Disadvantage: slow acting (6-7min for IM), increased risk of HTN, vomiting, HA, not heat stable

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Syntometrine (ergometrine, oxytocin)

A

Advantage: rapid effect of oxytocin, sustained action of ergometrine
Disadvantage: HTN, N/V, not heat stable

17
Q

Misoprostol

A

Class: Prostaglandin E1 analog
TX: Induce labor, nonsurgical abortions
Advantage: low cost, PO, PV, PR, heat stable
Disadvantage: rare amniotic fluid embolism, possible torn uterus *more common in women who have had previous uterine surgery, C-section

18
Q

Tamoxifen and bicalutamide

A

MOA: Bind to ER or PR positive tumors
TX: Breast CA, Prostate CA

19
Q

Tamoxifen

A 
Class: SERM
MOA: 
-Estrogen-like effects: uterus, bone, lipid metabolism
-Anti-estrogen-like effects: breast
TX: breast CA
20
Q

Raloxifene

A

Class: SERM
MOA:
-Estrogen-like effects: bone, lipid metabolism
-Anti-estrogen-like effects: breast, uterus
TX: uterine and breast CA
*reduce vertebral fractures but undesirable SE: heart risk, blood clots

21
Q

Idoxifene

A

Class: SERM
MOA:
-Estrogen-like effects: bone, lipid metabolism
-Anti-estrogen-like effects: breast, uterus

22
Q

Ospemifene

A

Class: SERM
Tx: Dyspareunia
*Oral

23
Q

Clomiphene

A

Class: partial agonist/antagonist of estrogen
MOA: Blocks estrogen feedback to increase GnRH, LH, FSH
Tx: infertility treatment

24
Q 
Type 1 (steroidal inactivators: androstenedione): Formestane, exemastane
Type 2 (nonsteroidal inactivators): Anastrozole, virazole, letrozole
Nonselective: aminoglutethimide
A

Class: aromatase inhibitor
MOA: inhibit aromatase, which converts androgens to estrogens
*second-line tx for breast CA patients when tamoxifen tx unsuccessful

25
Q

Mifepristone (RU-486)

A

Class: progesterone antagonist
MOA: causes uterine lining to shed, dislodging embryo
SE: excessive bleeding

26
Q

Levonorgestrel (Plan B)

A

MOA: prevents fertilization by decreasing ovulation, close cervix to sperm
*use within 72hrs

27
Q

ulipristal (Ella)

A

Class: SPRM
MOA: anti-progestin
*use within 120hrs

28
Q

Yuzpe regimen (Preven)

A

Use both estrogen and progestin

29
Q

danazol

A

MOA: modulate PR and partial agonist for AR
TX: endometriosis

30
Q

leuprolide

A

MOA: agonist at pituitary GnRH receptors
TX: endometriosis

PHCOL 401 (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions