Drugs Exam 1 Flashcards

1
Q

Rifampin

A
  • antibiotic that inhibits bacterial transcription
  • binds to beta subunit of bacterial RNA polymerase
  • used to treat TB
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2
Q

alpha-amanitin

A
  • poison that inhibits transcription in eukaryotes bu binding to RNA polymerase II
  • found in death cap mushroom
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3
Q

Inhibitors of translation initiation (prokaryotes)

A

*streptomycin
aurintricarboxylic acid
kasugamycin

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4
Q

Inhibitors of translation enlongation via aminoacyl-tRNA binding (prokaryotes)

A

*streptomycin
tetracyclin
kirromycin

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5
Q

Inhibitors of translation enlongation via peptide bond formation (prokaryotes)

A

*clindamycin
erythromycin
sparsomycin
chloramphenicol

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6
Q

Inhibitors of translation translocation

A

diptheria toxin
cyclohexamide
thiostrepton

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7
Q

Ricin

A

ribosome inactivation

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8
Q

SGLT2 inhibitors

A

used to treat DM2 by limiting glucose absorption in kidney

EX. canagliflozin, dapagliflozin

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9
Q

Mitotic inhibitors

A
  • target microtubules and inhibit their dynamics
  • freezes cells in mitosis and kills cells
  • targets cancer cells bc they are highly mitotic
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10
Q

Drugs that modulate actin dynamics

A

Phalloidin
Cytochalasin
Latrunculin

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11
Q

Sulfonylurea drug class

A

Inhibits ATP-sensitive K+ channels in pancreatic beta cells and increase insulin release

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