Drugs Exam 1

Question 1

Rifampin

Answer 1

• antibiotic that inhibits bacterial transcription
• binds to beta subunit of bacterial RNA polymerase
• used to treat TB

Question 2

alpha-amanitin

Answer 2

• poison that inhibits transcription in eukaryotes bu binding to RNA polymerase II
• found in death cap mushroom

Question 3

Inhibitors of translation initiation (prokaryotes)

Answer 3

*streptomycin
aurintricarboxylic acid
kasugamycin

Question 4

Inhibitors of translation enlongation via aminoacyl-tRNA binding (prokaryotes)

Answer 4

*streptomycin
tetracyclin
kirromycin

Question 5

Inhibitors of translation enlongation via peptide bond formation (prokaryotes)

Answer 5

*clindamycin
erythromycin
sparsomycin
chloramphenicol

Question 6

Inhibitors of translation translocation

Answer 6

diptheria toxin
cyclohexamide
thiostrepton

Question 7

Ricin

Answer 7

ribosome inactivation

Question 8

SGLT2 inhibitors

Answer 8

used to treat DM2 by limiting glucose absorption in kidney

EX. canagliflozin, dapagliflozin

Question 9

Mitotic inhibitors

Answer 9

• target microtubules and inhibit their dynamics
• freezes cells in mitosis and kills cells
• targets cancer cells bc they are highly mitotic

Question 10

Drugs that modulate actin dynamics

Answer 10

Phalloidin
Cytochalasin
Latrunculin

Question 11

Sulfonylurea drug class

Answer 11

Inhibits ATP-sensitive K+ channels in pancreatic beta cells and increase insulin release