Drugs Exam 1 Flashcards
Rifampin
- antibiotic that inhibits bacterial transcription
- binds to beta subunit of bacterial RNA polymerase
- used to treat TB
alpha-amanitin
- poison that inhibits transcription in eukaryotes bu binding to RNA polymerase II
- found in death cap mushroom
Inhibitors of translation initiation (prokaryotes)
*streptomycin
aurintricarboxylic acid
kasugamycin
Inhibitors of translation enlongation via aminoacyl-tRNA binding (prokaryotes)
*streptomycin
tetracyclin
kirromycin
Inhibitors of translation enlongation via peptide bond formation (prokaryotes)
*clindamycin
erythromycin
sparsomycin
chloramphenicol
Inhibitors of translation translocation
diptheria toxin
cyclohexamide
thiostrepton
Ricin
ribosome inactivation
SGLT2 inhibitors
used to treat DM2 by limiting glucose absorption in kidney
EX. canagliflozin, dapagliflozin
Mitotic inhibitors
- target microtubules and inhibit their dynamics
- freezes cells in mitosis and kills cells
- targets cancer cells bc they are highly mitotic
Drugs that modulate actin dynamics
Phalloidin
Cytochalasin
Latrunculin
Sulfonylurea drug class
Inhibits ATP-sensitive K+ channels in pancreatic beta cells and increase insulin release