Drugs, Exam 1 Flashcards
infliximab
use/class mechanism side effect (main)
rheumatoid arthritis
biologic DMARD
monoclonal antibody that inhibits TNF-alpha
serious infection (TB, viruses, fungi, etc.)
tofacitinib
use/class mechanism side effect (main)
rheumatoid arthritis
biologic DMARD
Janus kinase3 (JAK3) inhibitor - interfere with JAK-STAT signaling pathway (decreases inflammatory response)
serious infection
adalimumab
use/class mechanism side effect (main)
rheumatoid arthritis
biologic DMARD
monoclonal antibody that inhibits TNF-alpha
serious infection (TB, viruses, fungi, etc.)
tocilizumab
use/class mechanism side effect (main)
rheumatoid arthritis
biologic DMARD
monoclonal antibody that blocks IL-6 receptor/IL-6 interactions - suppress immune system
serious infection
denosumab
use
mechanism
osteoporosis
Human monoclonal antibody towards designed to inhibit RANKL therefore inhibiting the maturation of osteoclasts, hence a decrease in osteoclasts
etanercept
use/class mechanism side effect (main)
rheumatoid arthritis
biologic DMARD
inhibit TNF-alpha/receptor interactions (inhibits transcription cytokines, etc. from happening)
Immunosuppression (TB, viruses, fungi - infection risk)
methotrexate
use
class
mechanism
side effects
rheumatoid arthritis
traditional DMARD
irreversibly inhibits dihydrofolate reductase (DHFR), inhibits DNA/RNA/protein synthesis - suppressing immune system
teratogen
Abatacept
use/class mechanism side effect (main)
rheumatoid arthritis
biologic DMARD
T-cell costimulatory blocker. Block interactions between APC and T lymphocytes.
serious infection
Teriparatide
use
mechanism
anabolic agent (increases bone density) osteoporosis
Recombinant truncated form of Parathyroid Hormone, binds to PTH receptors on osteoblasts to stimulate RANKligand release
rituximab
use/class mechanism side effect (main)
rheumatoid arthritis
biologic DMARD
monoclonal antibody that binds to CD20 on B-cells, decreasing cytokine release, T-cell interactions, and reduces autoantibodies
serious infections
allopurinol
indication
mechanism
gout - more long term
a xanthine oxidase inhibitor, blocks uric acid production
alendronate
use/class mechanism
bisphosponates
osteoporosis
lines the bone, is absorbed by the osteoclast and kills the osteoclast by blocking an enzyme for cholesterol synthesis
ataluren
indication
mechanism
experimental muscular dystrophy drug
reads through premature stop codons
vitamin D
use
mechanism
osteoporosis
Increase serum concentration of calcium and phosphate by increasing GI absorption and decreasing renal excretion. Calcium and phosphate aid in bone building
zolendronic acid
use/class mechanism
bisphosponates
osteoporosis
lines the bone, is absorbed by the osteoclast and kills the osteoclast by blocking an enzyme for cholesterol synthesis
