Drugs and their Ocular Side effects

Question 1

Ocular side effects for Amiodarone

Answer 1

Cornea- Vortex Keratopathy
Lens- Anterior lens deposits
Optic nerve- Optic Neuropathy (rare)

Question 2

Ocular side effects for Hydroxycholoroquine

Answer 2

Cornea- Vortex Keratopathy
Macula- Toxic Maculopathy and Pigmentary Changes

Question 3

Ocular side effects of Tamoxifen

Answer 3

Cornea- Vortex Keratopathy
Macula- Toxic Maculopathy and refractile/ crystalline deposits

Question 4

Ocular side effects of Chlorpromazine

Answer 4

Cornea- Stromal/ Endothelial deposits
Conjunctiva- Pigmentary deposits
Lens- Stellate cataract
EOM function- Abnormal motility test/ Nystagmus

Anti- cholinergic action on the eye:
Mydriasis
Reduced aqueous tear secretions
Cycloplegia
Increased IOP

Question 5

Ocular side effects of minocycline and doxycycline

Answer 5

Conjunctiva- Inclusion cysts
Optic nerve- Optic nerve oedema

Question 6

Ocular side effects of Carbamazepine

Answer 6

Conjunctiva- Inclusion cysts and pigmentary deposits
EOM function- Abnormal motility test and Nystagmus

Question 7

Ocular side effects of Prednisolone, Dexamethasone and Hydrocortisone

Answer 7

Lens- Posterior Subcapsular cataract (PSCC)
IOP- Raised IOP, Reduced drainage
Macula- Macular oedema

Question 8

Ocular side effects of Topiramate

Answer 8

Ciliary body- Ciliary body oedema and Anterior shift of lens and iris
IOP- Angle closure and raised IOP

Question 9

Ocular side effects of Fingolimod

Answer 9

Macula- Oedema

Question 10

Ocular side effects of Vigabatrin

Answer 10

Optic nerve - Optic Neuropathy and resultant VF loss

Question 11

Ocular side effects of tamsulosin

Answer 11

Pupil/Iris (during cataract surgery)- intra-operative
floppy iris
syndrome (IFIS)
Poor pupil dilation
loss of the normal iris dilator
smooth muscle tone