Drugs and the kidneys

Question 1

What do you do with morphine and someone with impaired kidney function?

Answer 1

Lower the dose

Question 2

What do NSAIDS do?

Answer 2

Constrict afferent arterioles via inhibiting prostaglandins and lower GFR

Question 3

What do ACEI/ARB do?

Answer 3

Dilate efferent arterioles

Question 4

What can cause an allergic interstitial reaction?

Answer 4

Aminoglycosides, radiocontrast, NSAIDS, penicillin

Question 5

What causes hypokalaemia

Answer 5

Diuretics

Question 6

What causes hyperkalaemia?

Also, what drugs?

Answer 6

anything causing AKI

Drugs:

ACEI

ARB

All lower GFR so less secreted

Question 7

What causes irreversible kidney damage?

Answer 7

NSAIDS

Aminoglycosides

Question 8

What causes hyponatremia?

Answer 8

Loop diuretics, thiazide diuretics

Question 9

What causes falsely elevated CK?

Answer 9

Trimethoprim

Question 10

What causes hypercalcaemia?

Answer 10

Vit D/Calcium supplements

Question 11

What causes hyperuricaemia?

Answer 11

Chemo

Question 12

What causes rhabdomyolysis?

Answer 12

Statins, ciclosporin

Question 13

What does prostate cancer lead to and why?

Answer 13

Metabolic acidosis due to bone mets and increased osteoclast action causing acidosis