Drugs and CHD Flashcards
Define angina…
Crushing pain in chest that may radiate to arm, neck or jaw
Where does the pain arise from?
Cardiac ischemia
What are beta blockers mechanism of action?
Reduce heart rate
What are nitrovasodilators mechanism of action?
Reduce heart filling and contraction strength
BP lowering drugs mechanism of action is…
Reduce arterial resistance
Cholesterol lowering drugs e.g. statins mechanism of action…
Stop the formation of atheromas
Anti-platelett drugs mechanism of action is…
Decrease risk of clotting
For severe pain during an MI what would be given?
Strong pain killers e.g. morphine/diamorphine
During an MI, what would be given for arrhythmia’s?
Anti-arrhythmia drugs
During an MI, for the death of infarcted tissue what is given?
Clot busting drugs (thrombolytics)
What other drugs are used for MI…
Beta Blockers
Ace inhibitors
Anti-platelett therapies (make blood less likely to clot)
What is the most common nitrovasodilator?
GTN
How can nitrovasdilators be given?
Sublingual tablet, nasal spray, transdermal patch
How do nitrovasodilators work?
They mimic something body already does.
They produce nitric oxide and dilate arteries AND veins
Common side effects of nitrovasodilators are…
Headache
Dizzy
Tolerance
Caution with other bp drugs
What enzyme do statins inhibit and why?
HMG-CoA
To control cholesterol production in the liver and reduce LDL by imitating HMG-CoA.
Side effects of statins…
GI upset
Abnormal liver tests
Muscle probs
Does GTN reduce venous return?
Yes
What causes a reduction in diastolic blood pressure which is compensated for by an increase in heart rate…
GTN
