Drugs and Binding

Question 1

Affinity

Answer 1

how drug/neurotransmitter binds to post synaptic receptor (lock and key analogy)

Question 2

Efficacy

Answer 2

when drug is bound, does it produce an effect (opens door analogy)

Question 3

Partial agonsit

Answer 3

High affinity and High efficacy. Ex. Buprenorphine binds and only has minimal efficacy (reduces severity of withdrawal)

Question 4

Anatagonist

Answer 4

High affinity and No efficacy. When it binds it does nothing. But take more of the agonist and it will undue benefit of antagonist.

Question 5

Excitatory Neurotransmitters (Glutamate)

Answer 5

binds to post synaptic receptor and opens ion channel, leading to influx of sodium. It makes neuron more positive - depolarization (increasing chances of action potential firing)

Question 6

Inhibitory Neurotransmitters (GABA)

Answer 6

binds to post synaptic receptor and opens ion channel, leading to influx of calcium and potassium. Makes neuron more negative - hyperpolarization - decreasing chance of action potential firing)