Drugs against C Diff

Question 1

fidaxomicin MOA

Answer 1

macrolid - inhibits bacterial synthesis - no activity against gram negatives and no known cross-resistance

Question 2

fidaxomicin AE

Answer 2

similar to vanc (n/v, abdominal pain, bleeding)

Question 3

fidaxomicin clinical utility

Answer 3

better outcome and lower rate of recurrence than vanc but super fucking expensive

Question 4

metronidazole MOA

Answer 4

chemically reduced in anaerobic bacteria and the products are toxic to organism

Question 5

metronidazole AE

Answer 5

nausea, metallic taste, peripheral neuropathy

Question 6

metronidazole CI

Answer 6

pregnancy and breast feeding

Question 7

clinical utility for metronidazole

Answer 7

DOC for mild to moderate disease

Question 8

vanc MOA

Answer 8

binds to d-ala d-ala and prevents cell wall synthesis

Question 9

vanc AE

Answer 9

n/v, abdominal pain, bleeding

Question 10

clinical utility for vanc

Answer 10

DOC for severe & in pregnancy (rectal enema)

Question 11

stool transplant MOA

Answer 11

mostly instillation into lower GI tract but some have tried NG tube - promotes healthy bacterial environment

Question 12

stool transplant AE

Answer 12

extensive pathogen testing for donor needed