Drugs Flashcards
(NS) 3/4A protease inhibitor:
SE: fatique, HA, nausea
Grazoprevir
(NS) 3/4A protease inhibitor:
Broken down by CY3A , causing many drug-drug interactions. Solution?
Paritaprevir
SOLN: combine with “boosting” agent ritonavir, which prevents is a CYP3A blocker, preventing breakdown.
Nonstructural protein (NS) 3/4A protease inhibitor:
Paritaprevir SE
- Pruritis
- Nausea
- Insomnia
(NS) 3/4A protease inhibitor:
Which must be taken with food to maximize absorbption and is generally well tolerated?
Simeprevir
NS5B RNA polymerase inhibitors
Non-nucleoside NS5B allosteric inhibitor that is broken down by CYP3a => many drug drug interactions
Dasabuvir
NS5B RNA polymerase inhibitors
Dasabuvir symptoms
- Pruritis
- insomia
- N
NS5B RNA Polymerase Inhibitor
Which is a well- tolerated pro-drug and a NUCLEOTIDE analong?
Sofosbuvir
NS5A inhibitor
which is metabolized by CYP3a => portential drug/drug interactios
Elbasvir
Elbasvir can be taken with ________ and includes symptoms: _______
Elbasvir + Grazoprevir = fatique, HA, N
Ledipasvir can be taken with ________ and includes symptoms: _______
Ledipasvir + Sofosbuvir = fatique, HA, asthenia
Ombitasvir can be combined with ______
- Paritapreview
- Ritonavir
- Dasabuvir
- => boost the effects of these drugs by inhibiting CYP3A
Ombitivir side effects
- Prutitis
- Insominia
- N
_________ is the first 1x/day single-tablet with pangenotypic activity
Velpatasvir + Sofosbuvir = treats genotypes 1-6
paritaprevir + ritonavir + ombitasvir + dasabuvir + ribavirin
Which drug is boosting?
Which one has most AE?
- Ritonavir = booster
- Ribavirin
Managing patients co-infected with both HBV and HCV. Which do we treat?
Treat the most predominant virus (HepB)
Once that goes away, treat the other virus. (Hep C)
Once the HBV reactivates, treat with HepB specific drug.
