Drugs Flashcards
Whats the neurotransmitter ans receptor in somatic N.S?
ACh and nicotine receptors
What’s the neurotransmitter in autonomic N.S?
Ach –》nicotine》ach –》 muscarine
What is the neurotransmitter in parasympathetic N.S?
Ach》 nicotin》 ach》muscarine
What’s the neurotransmitter in sympathic N.S?
Ach》 nicotin》Nad 》alfa/beta
What’s the function of anticholinergic drugs?
Blocking the neurotransmitter ACh
What’s the anticholinergic drugs?
Antimuscarinic and antinicotinic
What’s the function of sympathic N.S?
Fight and flight
What’s the function of parasympathetic N.S?
Rest and digest
What’s the characteristics of the preganglion in parasympathetic N.S?
Lightly myelinated
Transmitters ACh
What’s the characteristics of a preganlionoc axon in the somatic N.S?
Meylated, ACh 》 skeletal muscle
What’s the characteristics of a postganlionic axon in parasympathetic N.S?
Unmeylated. Ach
What’s the characteristic of a sympathic postganglion?
Unmyelinated
What’s a anticholinergic drug?
It blocks the neurotransmitter ACh in the central and peripheral N.S
Two types receptors affected:
Nicotinic and muscarinic
MAJORY OF ANTICHOLINERGIC DRUGS ARE ANTIMUSCARINIC
Witch is the cholinergic receptors?
Nicotinic and muscarinic
What’s the function of anticholinergic drugs?
Blocking the action of ACh in central and peripheral N.S, this inhibits nerveinpulses responsible for involuntary muscle movements and various body functions
What is a antimuscarinic agent?
Operate on the muscarinic receptor = mAChR BLOCKERS (majority of all anticholinergic drugs are antimuscarinic)
What is parasympatholytic agent?
An anticholinergic agent that INHIBITS the transmission of ACh mediated stimulation by competitive occupancy (antagonist) of cholinergic receptors of postganlionic parasympathetic nerves. MUSCARINIC RECEPTORS is modified and smooth muscle and secretorycells effected
what is the function of anticholinergic drug?
it blocks the neurotransmitter ACH in the central and peripheral nervous system by blockiing the cholinergic receptors of postganlionic of parasympathetic (muscarinic)
what is the function of antimuscarinic agents?
the modify the muscarinic effects of ACH on smoot muscle and sensorycells but NOT the nicotinic effects on ganlionic transmission points and endplates of the skeletal muscles.
in heart block cardioinhibitor effect on muscarinic receptor in the sinus node by ACH release from the vagalnerve (parasymptatetick nerve)
what is atropine?
anticholinergic agent that blocks ach in central an peripheral N.S
what is anticholinesterase?
an agent thats inhinbits the acetylcholinesterase ensyme —> no hydrolysis of ACH—> increasing borh level and duration of action of the neurotransmiiter ACG —> muscular spasm –> spatic paralysis
