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Psychiatry > Drugs > Flashcards

Drugs Flashcards

1
Q

What is the principle neurotransmitter that anti-psychotics act on?

A

Dopamine

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2
Q

Which anti-psychotic is a partial dopamine antagonist?

A

Aripiprazole

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3
Q

What are the side effects of typical antipsychotics?

A

Parkinsonism
Tardive dyskinesia
Akathisia
Hypersalivation

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4
Q

What are the common side effects of atypical anti-psychotics?

A

Metabolic side effects e.g. Impaired glucose tolerance, weight gain and increased prolactin

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5
Q

What is a common side effect of all antipsychotics except one and which is it?

A

Prolonged QTc except aripirazole

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6
Q

What is the indication for initiating clozapine and what are serious side effects?

A

Failure of two other antipsychotics

Risk of agranulocytosis

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7
Q

How should clozapine be monitored?

A

Weekly blood tests initially and then monthly. If 48hrs of medication missed must be retitrated

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8
Q

What are other common side effects of clozapine?

A

Hypersalivation
Tachycardia
Nocternal enuresis

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9
Q

What is neuroleptic malignant syndrome and what occurs it?

A

Medical emergency
Presents with hyperthermia, confusion, sweating and hypertonia.
Occurs with any antipsychotic medication

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10
Q

What are side effects of lithium therapy?

A

Increased urination, headache, fine tremor and GI

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11
Q

What are risks of long term lithium therapy?

A

Thyroid and Kidney dysfunction

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12
Q

What are symptoms and causes of lithium toxicity?

A

Life threatening emergency
Often triggered by infections, leading to dehydration and accumulation to lithium

Presents with GI disturbance, progression from fine to coarse tremor, ataxia, confusion and drowsiness.

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13
Q

What are the initial screening blood tests and what is the monitoring involved with lithium therapy?

A

Initial screening for TFT and GFR

3 monthly levels and GFR
6 monthly weight and TFT

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14
Q

What are side effects of SSRI?

A

GI upset
Increased arousal initially
Insomnia
QTC prolongations

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15
Q

What are examples of SNRI and NaSSA and when are they indicated?

A

Venlafaxine and Duloxetine

NaSSA = Mirtazapine

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16
Q

What are symptoms of serotonin syndrome and when are is there an increased ?

A

Sweating, increased reflexes and tremulous

When combined with lithium, triptans and opiates

17
Q

What is an example MAO inhibitor?

A

Moclobemide

18
Q

What is the risk associated MAOI?

A

Tyramine reaction if patients eat foods high in tyramine present with hypertensive crisis

Psychiatry (4 decks)

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