Drugs Flashcards
Zofran - generic name
Ondansetron
Zofran (ondansetron) - Class:
Antiemetic
Zofran (ondansetron) - Action
Blocks serotonin receptors in the vagus nerve terminals and in small intestine that trigger the vomit reflex
Zofran (ondansetron) - Onset and Duration
Onset: IV/IM and ODT up to 30 minutes
Duration: IV/IM and ODT 2 hours
Zofran (ondansetron) - Indications
Abdominal Discomfort - GI/GU (non traumatic) - (S-120)
- for nausea or vomiting
Pain Management, (S-141)
- for nausea or vomiting after morphine administration
Pediatric:
GI/GU (non traumatic), (S-174)
- nausea or vomiting
Zofran (ondansetron) - Dosage
Adults:
4mg IV/IM/ODT
MR x1 in 10”
PEDS:
6mo - 3 years: 2mg ODT/IV
>3 years: 4mg ODT/IV
*if suspected head injury, BHPO
Zofran (ondansetron) - Contraindications
None
Zofran (ondansetron) - Side effects
- GI issues (especially diarrhea)
- headache
Benadryl - generic name:
(Diphenhydramine Hydrochloride)
Benadryl (Diphenhydramine Hydrochloride) - Class:
Antihistamine
Benadryl (Diphenhydramine Hydrochloride - Action:
- Binds with histamine receptors, blocking H1 and H2 receptors
H1 causes bronchoconstriction, airway swelling, and vasodilation
H2 causes secretion of gastric acid - does not prevent release of histamine
Benadryl (Diphenhydramine Hydrochloride - Onset and Duration
Onset: 15-30 minutes
Duration: 6-12 hours
Benadryl (Diphenhydramine Hydrochloride - Indications
- Allergic Reaction/Anaphylaxis, (S-122, S-162)
(Hives/Anaphylaxis Criteria/Angioedema) - Poisoning/OD, (S-134, S-165)
Extrapyramidal reactions
Benadryl (Diphenhydramine Hydrochloride - Dosage/Route
Adults: 50mg slow IV/IM
PEDS: PDC IV/IM
Benadryl (Diphenhydramine Hydrochloride - contraindications
None
Benadryl (Diphenhydramine Hydrochloride - side effects:
- Drowsiness/sedation (excitement in children)
- Dry mouth/ thickened bronchial secretions
- Hypotension
- Palpitations/tachycardia
Epinephrine (Adrenalin, EPI) - Class
Catecholamine: Sympathomimetic (both alpha and beta effects)
Epinephrine (Adrenalin, EPI) - Action:
- On the bronchi: bronchodilation (beta-2)
- On the peripheral vasculature: vasoconstriction (alpha)
- On the heart:
- increased heart rate (beta-1)/chronotropic
- increased contracility/inotropic
- increased AV conduction/dromotropic
- increased automaticity/dromotropic
Epinephrine (Adrenalin, EPI) - Onset and Duration
Onset:
- IV/IO 1-2 minutes - IM/SC 5-10 minutes
Duration:
- IV/IO 5-10 minutes - IM/SC 1-4 hours
Epinephrine (Adrenalin, EPI) - Indications (only)
- Allergic Reaction/Anaphylaxis, (S-122, S-162)
anaphylaxis/angioedema - Respiratory Distress, (S-136, S-167)
Severe respiratory distress or inadequate response to Albuterol/ Atrovent - PEDS: Respiratory distress (S-167)
With stridor at rest - PEDS: Burns (S-170)
with respiratory distress with stridor - Dysrythmias (S-127, S-163)
Cardiac arrest (pulseless patient) - PEDS: Dysrhythmias (S-163)
Unstable bradycardia: after BVM for 30 seconds - PEDS: Newborn deliveries (S-166)
If HR remains <60 after 30 seconds of CPR
Epinephrine (Adrenalin, EPI) - Dosage
Allergic Reaction/Anaphylaxis, (S-122; S-162)
- anaphylaxis/angioedema
Adult= .3mg IM 1:1,000 MR x2 q5”
.1mg IV/IO 1:10,000 BHO; MR x2 q3-5” BHO
PEDS= PDC IM 1:1,000; MR x2 q5”
PDC IV/IO 1:10,000 BHO; MR x2 q3-5” BHO
Epinephrine: Dosage for
PEDS: Newborn deliveries (S-166)
- (if HR remains <60 after 30 seconds of CPR)
PEDS: PDC IV/IO 1:10,000 - MR x2 q3-5” BHO
Epinephrine (adrenaline, EPI): Dosage
for PEDS: Dysrhythmias, (S-163)
- (unstable cradycardia: after BVM for 30 sec):
PEDS: PDC IV/IO 1:10,000 - MR x2 q3-5” BHO
Epinephrine (adrenaline, EPI): Dosage
Dysrhythmias, (S-127; S-163)
- cardiac arrest/pulseless patient
PEDS: Dysrhythmias (S-163)
- unstable bradycardia: after BVM for 30 sec
Adults: 1mg IV/IO 1:10,000 - MR q3-5”
PEDS: PDC IV/IO 1:10,000; MR x2 q3-5”; MR q3-5” BHO
Epinephrine - Dosage:
PEDS: Burns, (S-170)
- with Respiratory distress with stridor:
PEDS:
1: 1,000 PDC via nebulizer MR x1 SO 1: 1,000 PDC IM, SO MR x2 q5” SO
Epinephrine (adrenaline, EPI): Dosage
PEDS: Respiratory Distress, (S-167)
- with stridor at rest:
PEDS: 1:,1000 PDC via nebulizer MR x1
Epinephrine: Dosage
Respiratory Distress, (S-136, S-167)
- severe respiratory distress or inadequate response to Albuterol/Atrovent):
Adults= .3mg IM 1:1,000; MR x2 q5”
*if no definite history of asthma: dosing as above per BHPO
PEDS= PDC - IM 1:1,000; MR x2 q5”
Epinephrine (Adrenalin, EPI) - Contraindications:
None
Epinephrine (Adrenalin, EPI) - side effects:
- anxiety/restlessness
- palpitations/tachyarrhythmias
- Ventricle irritability
- increased myocardial 02 demands
- hypertension
- angina
Narcan (Naloxone Hydrochloride)- Class?
Opioid antagonist
Narcan (Naloxone Hydrochloride)- Action
Reverse respiratory depression, sedation and hypotension effects of opioid overdose by occupying opiate receptor sites
Narcan (Naloxone Hydrochloride)- Onset and Duration
Onset: IV/IN 1-2 min
IM 2-5 min
Duration: IV 30-60 min
IM longer
Narcan (Naloxone Hydrochloride)- Indications
Adult: Poisoning/OD Altered Neurological (symptomatic suspected opioid OD with respirations <12
PEDS: Poisoning/OD Altered Neurological (symptomatic suspected opioid OD)
Narcan (Naloxone Hydrochloride)- Dosage/Route
Adult: 2mg IN/IM/IV; MR titrate IV dose to effect, to drive the respiratory rate
IF patient refuses transport: 2mg IM additional dose
PEDS: PDC IN/IM/IV; MR
Adults/PEDS: for opioid dependent pain management patients: “use caution and titrate”
Narcan (Naloxone Hydrochloride)- Contraindications
None
Narcan (Naloxone Hydrochloride)- Side Effects
- Acute withdraws symptoms
- Nausea/vomiting
- Tachycardia/hypertension
Glucagon- Class
Antihypoglycemic: pancreatic hormone
Glucagon- Action
- Increases blood glucose by converting glycogen stored in the liver to glucose
- Inhibits synthesis of glycogen from glucose
Glucagon- Onset and Duration
Onset: 20 min
Duration: 60-90 min
Glucagon- Indications
- Altered Neurological
Symptomatic Hypoglycemia: symptomatic patient with altered LOC
Or…
Unresponsive to organ glucose agents “IF no IV” and blood sugar:
Adults/PEDS/Infants = BS <60 Neonate= BS <45
Glucagon- Dosage/Route
Adult: 1ml (1 unit) IM
PEDS: PDC, IM
Glucagon- contraindications
None
Glucagon- side effects
- Nausea/vomiting
- Tachycardia/ HTN
Acetaminophen (Ofirmev) - Class
Analgesic/Antipyretic
Acetaminophen (Ofirmev) - Action
- Inhibits the synthesis of prostaglandins which transmit pain signals and induce fever
- Reduces pain by blocking the signals produced by prostaglandins
Acetaminophen (Ofirmev) - Onset and duration
Onset: 15 min, PEAK = 1 hour
Duration: up to 4-6 hours
Acetaminophen (Ofirmev) - Indications
For treatment of pain as needed (S-141, S173)
- Abdominal Pain
- Burns
- Envenomation injury
- Trauma
- Pain or discomfort of suspected cardiac origin
- Pain associated with external pacing
Acetaminophen (Ofirmev) - dosage and route
Adult: 1,000mg IV x1 SO. Infuse over 15 min.
PEDS: ≤2 y/o PDC, SO x1 infuse over 15 min.
BHPO required for:
Chronic pain state; isolated head injury; acute onset severe headache; drug/etoh; intoxication; multiple trauma with GCS <15; suspected active labor
Maximum total daily dose: 4,000mg in 24 hrs
Acetaminophen (Ofirmev) - Contraindications
- <2 years of age
- Severe hepatic impairment
- Severe active liver disease
- If known or suspected total dose exceeding 4,000mg in 24hr period
Acetaminophen (Ofirmev) - side effects
- Nausea, vomiting
- Headache, sleep problems
- Constipation
- Itching, agitation
- Partial or total lung collapse in pediatric patients
Adenosine (Adenocard) - class
Antiarrhythmic
Adenosine (Adenocard) - Action
Slows electrical conduction through AV node and interrupts re-entry pathway, converting SVT to NSR
Adenosine (Adenocard) - Onset and Duration
Onset = within 30 seconds
Duration = 1-2 minutes
Adenosine (Adenocard) - ADULT indications/dosage
Adult: Dsyrhythmias
- SVT
Dosage:
6mg rapid IV/IO; follow with rapid 20ml NS
12mg rapid IV/IO; follow with rapid 20ml NS
If no sustained rhythm changes, MR x1 in 1-2”
If patient has history of bronchospasm or COPD: Dosing as above per BHPO
Adenosine (Adenocard) - PEDS, indication/dosage
PEDS: Dysrhymtias
-unstable SVT
Dosage:
1st dose PDC Prado IV, BHPO… follow with NS 20ml rapid IV
2nd dose PDC rapid IV, BHPO… follow with NS 20ml rapid IV
If no sustained rhythm change, MR x1 BHPO
Adenosine (Adenocard) - contraindications
- 2nd and 3rd degree AV heart blocks
- Sick sinus syndrome (without pacemaker)
Adenosine (Adenocard) - side effects
- SOB/dyspnea; may cause bronchospasm in COPD patients (BHO)
- Chest pressure/palpitations
- Facial flushing/headache
- Dizzy/lightheaded ness
- Nausea
- Transient Arrhythmias (PVC’s, PAC’s, sinus bradycardia, AV block, sinus tach or asystole).
These are generally not treated and are quickly self-limiting
Albuterol (proventil, ventolin) - class
Bronchodilator: sympathomimetic (beta-2 specific)
Albuterol (proventil, ventolin) - action
- Relaxes bronchial smooth muscles by stimulating beta-2 adrenergic receptors
- Produces bronchodilation, relieves bronchospasm, and reduces airway resistance
Albuterol (proventil, ventolin) - Onset and Duration
Onset: 5 minutes, PEAK = 1 hour
Duration: up to 5 hours
Albuterol (proventil, ventolin) - Indications
Respiratory Distress
- suspected non-cardiac
Allergic Reaction/Anaphylaxis
- acute allergic reactions or anaphylaxis
Burns
- respiratory distress with bronchospasm
- Hemodialysis Patient
- symptomatic, suspected hyperkalemia if ≥72 hrs since last dialysis
Albuterol (proventil, ventolin) - Dosage/Route
Dosage for: respiratory distress; allergic reaction/Anaphylaxis; burns:
Adult = 6ml (.083%) via nebulizer MR
PEDS = PDC via nebulizer MR
Dosage for Hemodialysis Patient:
Adult= Continuous 6ml (.083%) via nebulizer MR
Albuterol (proventil, ventolin) - contraindications
- none in adults
- PEDS: for croup/stridor (nebulizer saline/epinephrine is indicated)
Albuterol (proventil, ventolin) - side effects
- Tachycardia/palpitations
- Dizziness, headache
- Tremors, nervousness
Aminodrone Hydrochloride (cordarone, pacerone, nexterone):
Class
Antiarrhythmic
Aminodrone Hydrochloride (cordarone, pacerone, nexterone),
Action
- Blocks sodium, potassium, and calcium channels in cardiac cells slowing conduction and prolongs repolarization
- Has alpha and beta adrenergic blocking properties causing negative inotropic effects and reduces peripheral vascular resistance (afterload)
Aminodrone Hydrochloride (cordarone, pacerone, nexterone),
Onset and Duration
Onset: minutes
Duration: Days
Aminodrone Hydrochloride (cordarone, pacerone, nexterone),
Indications
Dysrhythmias - stable ventricular tachycardia (SVT)
Dysrhythmias - reported/witnessed ≥2 AICD with pulse ≥60
Dysrhythmias - VF/Pulseless VT: After 1st shock if still refractory
Aminodrone Hydrochloride (cordarone, pacerone, nexterone),
Dosage/Route (per indication)
Dysrhythmias, Stable SVT:
Adults ONLY: 150mg in 100ml of NS over 10” IV/IO. MR x1 in 10” BHPO
Dysrhymias, reported witnessed ≥ x2 AICD with pulse ≥60:
Adults ONLY: 150mg in 100ml of NS over 10” IV/IO BHO
Dysrhymias, VF/Pulseless VT: after 1st shock if still refractory:
Adult= 300mg IV/IO, MR 150mg (max of 450mg)
PEDS= PDC IV/IO, MR q3-5” x2. SO
Aminodrone Hydrochloride (cordarone, pacerone, nexterone),
Contraindications
- Hypotension
- 2nd and 3rd degree heart block
- Idioventricular rhythms
Aminodrone Hydrochloride (cordarone, pacerone, nexterone),
Side effects
- Hypotension
- Exacerbation of presenting arrhythmia after days of use
- Liver injury
- Pulmonary injury: pulmonary infiltrates, bronchospasm, SOB cough, he Optus is, hypoxia
Aspirin, ASA (acetylsalicylic acid)- Class:
platelet aggregation inhibitor
Aspirin, ASA (acetylsalicylic acid)- Actions:
- Inhibits normal tendency for platelets to accumulate inside injured or occluded coronary arteries, thereby improving blood flow through vessels to better perfume the heart
- Blocks formation of Thromboxin A2
Aspirin, ASA (acetylsalicylic acid)- Onset and Duration
Onset= 15-30 min
Duration = days (antiplatelet effects)
Aspirin, ASA (acetylsalicylic acid)- Indications and route/dosage
Indications= Discomfort/Pain of suspected cardiac origin
Dosage/Route= Adult ONLY: 324mg PO (four 81mg chewable tablets)
Aspirin, ASA (acetylsalicylic acid)- Contraindications
None
Aspirin, ASA (acetylsalicylic acid)- Side effects
- GI upset (indigestion, nausea/vomiting, epigastric pain, heartburn)
- Occult or prolonged bleeding
Atropine Sulfate- Class
- antiarrhythmic
- anticholinergic
Atropine Sulfate- Actions
- Competes with acetylcholine for receptor sites blocking the PNS response at SA & AV nodes
- Increases heart rate by increasing electrical conduction through the heart
- Positive chronotropic properties with little or no inotropic effects
- Inhibits secretions by decreasing PNS effect on bronchial, salivary, sweat and GI glands
Atropine Sulfate- Onset and Duration
Onset= IV/IO 2-4 min; IM 10-15 min
Duration= 2-6 hours
Atropine Sulfate- Indications
Adult: Dysrhymias
- unstable bradycardia: narrow complex
Adult: Dysrhymias
- unstable bradycardia: wide complex if external pacemaker unavailable
PEDS: Dysrhymias
- unstable bradycardia: after BVM for 30 sec. and 3rd dose of Epinephrine
Poisoning/OD
- symptomatic organophosphate poisoning
Atropine Sulfate- Dosage/Route for Adult Dysrhymias (unstable bradycardia: narrow complex)
Adult: .5mg IV/IO for pulse <60; MR q3-5” to max 3mg
Atropine Sulfate- Dosage/Route for
Adult: Dysrhythmias (unstable bradycardia: wide complex if external pacemaker unavailable)
Adult: May give Atropine .5mg IV/IO for pulse <60, MR q3-5” to max 3mg
Atropine Sulfate- Dosage/Route for
PEDS: Dysrhymias (unstable bradycardia: after BVM for 30 sec and 3rd dose of epinephrine
PEDS: <9 years, HR<60
9-14 years, HR <40
PDC IV/IO; MR x1 in 5”