Drugs Flashcards
MDMA (ecstasy)
reverses direction of SERT & blocks reuptake –> 5-HT extruded OUT of cell
Fenfluramine
VMAT blocker –> increases 5-HT in extracellular space
LSD
Serotonin receptor agonist
Antipsychotics
Serotonin receptor antagonist
Fluoxetine
SSRI (prozac)
Sertraline
SSRI (zoloft)
Paroxetine
SSRI (paxil)
Citalopram
SSRI (celexa)
Trazodone
Serotonin, NE receptor antagonist
Mirtazapine
Serotonin, NE, Dopamine receptor antagonist
Triptans
Serotonin receptor agonists (2C receptor) –> vasoconstriction
Carbidopa
Inhibits L-AAAD in the periphery
Disulfiram
Inhibits dopamine B-hydroxylase; inhibits acetaldehyde dehydrogenase (metabolism of acetaldehyde)
Reserpine
VMAT blocker –> increases 5-HT in extracellular space
Cocaine
Blocks reuptake of NE; Blocks dopamine transporter to inhibit reuptake
Imipramine
Blocks reuptake of NE, serotonin
Prednisone
synthetic corticosteroid
Chlorpromazine (Thorazine)
1st generation antipsychotic (low potency); block Dopamine at D2 receptor
Iproniazid
MAO inhibitor
Haloperidol
1st generation antipsychotic (high potency); block Dopamine at D2 receptor
Abilify (Aripiprazole)
2nd generation antipsychotic; block D2 and 5-HT receptors
Clozapine (Clozaril)
2nd generation antipsychotic; block D2 and 5-HT receptors
Lithium
Stabilize neuronal membrane by blocking voltage-gated Na+ channels