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Brain and Behavior II > Drugs > Flashcards

Drugs Flashcards

1
Q

MDMA (ecstasy)

A

reverses direction of SERT & blocks reuptake –> 5-HT extruded OUT of cell

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2
Q

Fenfluramine

A

VMAT blocker –> increases 5-HT in extracellular space

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3
Q

LSD

A

Serotonin receptor agonist

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4
Q

Antipsychotics

A

Serotonin receptor antagonist

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5
Q

Fluoxetine

A

SSRI (prozac)

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6
Q

Sertraline

A

SSRI (zoloft)

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7
Q

Paroxetine

A

SSRI (paxil)

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8
Q

Citalopram

A

SSRI (celexa)

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9
Q

Trazodone

A

Serotonin, NE receptor antagonist

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10
Q

Mirtazapine

A

Serotonin, NE, Dopamine receptor antagonist

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11
Q

Triptans

A

Serotonin receptor agonists (2C receptor) –> vasoconstriction

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12
Q

Carbidopa

A

Inhibits L-AAAD in the periphery

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13
Q

Disulfiram

A

Inhibits dopamine B-hydroxylase; inhibits acetaldehyde dehydrogenase (metabolism of acetaldehyde)

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14
Q

Reserpine

A

VMAT blocker –> increases 5-HT in extracellular space

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15
Q

Cocaine

A

Blocks reuptake of NE; Blocks dopamine transporter to inhibit reuptake

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16
Q

Imipramine

A

Blocks reuptake of NE, serotonin

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17
Q

Prednisone

A

synthetic corticosteroid

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18
Q

Chlorpromazine (Thorazine)

A

1st generation antipsychotic (low potency); block Dopamine at D2 receptor

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19
Q

Iproniazid

A

MAO inhibitor

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20
Q

Haloperidol

A

1st generation antipsychotic (high potency); block Dopamine at D2 receptor

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21
Q

Abilify (Aripiprazole)

A

2nd generation antipsychotic; block D2 and 5-HT receptors

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22
Q

Clozapine (Clozaril)

A

2nd generation antipsychotic; block D2 and 5-HT receptors

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23
Q

Lithium

A

Stabilize neuronal membrane by blocking voltage-gated Na+ channels

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24
Q

Benzodiazepines

A

Increase opening Cl- channel via GABA(A) receptor

25
Q

Librium (Chlordiazepoxide)

A

Increase opening Cl- channel via GABA(A) receptor (low potency/long t1/2)

26
Q

Aricept

A

AChE inhibitor

27
Q

Namenda

A

NMDA receptor antagonist

28
Q

Naltrexone

A

Opioid receptor antagonist

29
Q

Acamprosate

A

Glutamatergic NMDA receptor antagonist; GABA-A agonist

30
Q

Topiramate

A

AMPA (Glu) receptor antagonist; increases GABA-A activity

31
Q

Morphine

A

Mu Opioid Receptor Agonist

32
Q

Clonidine

A

a2-adrenergic receptor antagonist; inhibits NE release; treats HTN, panic attacks, RLS

33
Q

Buprenorphine

A

Partial Mu Opioid receptor agonist

34
Q

Methadone

A

Mu Opioid receptor agonist (full)

35
Q

Naloxone

A

Opioid inverse agonist

36
Q

Bupropion SR (Zyban)

A

Dopamine and norepipnephrine reuptake inhibitor and releaser

37
Q

Varenicline

A

Partial NAchR agonist

38
Q

Electroconvulsive Therapy

A

Brain defibrillator; acute Glu/GABA/monoaminergic function; alter neuronal connectivity

39
Q

Transcranial Magnetic Stimulation

A

Induced electrical current in cortex

40
Q

Magnetic Seizure Therapy

41
Q

Vagal Nerve Stimulation

A

stimulation of CNX and activation of monoaminergic nerves

42
Q

Deep Brain Stimulation

A

Neural jamming via focal insertion of electrodes

43
Q

Xanax (Alprazolam)

A

Potentiate activity at GABA-A receptor (high potency/short t1/2)

44
Q

Lorazepam (Ativan)

A

Potentiate activity at GABA-A receptor (high potency/short t1/2); BYPASS LIVER

45
Q

Klonopin (Clonazepam)

A

Potentiate activity at GABA-A receptor (high potency/long t1/2)

46
Q

Oxazepam

A

Potentiate activity at GABA-A receptor low potency/short t1/2); BYPASS LIVER

47
Q

Valium (Diazepam)

A

Potentiate activity at GABA-A receptor low potency/long t1/2)

48
Q

Amphetamine (Adderall)

A

Binds to monoamine transporters and increases neuronal concentrations of dopamine

49
Q

Methylphenidate (Ritalin)

A

NE / Dopamine reuptake inhibitor

50
Q

Methamphetamine

A

Reverses flow of 5-HT/NE/D transporters (NT –> cytoplasm –> synapse)

51
Q

Oxycodone

A

K-opioid agonist / M-opioid agonist (disputed)

52
Q

Heroin

A

M-opioid agonist

53
Q

Morphine

A

M-opioid agonist

54
Q

Cocaine Vaccine

A

Cocaine molecule + cholera vaccine –> cocaine-specific antibody

55
Q

Marijuana

A

CB1 receptor agonist

56
Q

Nicotine

A

Nictonic acetylcholine receptor agonist –> increased dopamine in reward circuits

57
Q

Dronabinol

A

Cannabinoid agonist

58
Q

Nabilone

A

Cannabinoid agonist

Brain and Behavior II (3 decks)

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