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Brain and Behavior II > CNS Tumor Features > Flashcards

CNS Tumor Features Flashcards

1
Q

Grade II glioma, no mitoses

A

Astrocytoma (diffuse)

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2
Q

Plump cells, glassy pink cytoplasm

A

Diffuse astrocytoma - gemicystic variant

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3
Q

Grade III glioma, mitoses

A

Anaplastic Astrocytoma

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4
Q

Multilayered glomeruloid tufts

A

Glioblastoma

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5
Q

Pseudopalisading necrosis

A

GBM. Palisading is when cells line up next to each other, like slats in a picket fence. These rapidly proliferating tumor cells (area outlined in green) appear to palisade around the central pale area, which represents necrotic tissue (region shaded in yellow).

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6
Q

Endothelial (microvascular) proliferation

A

GBM; several layers of endothelial cells filling lumen of vessel

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7
Q

Ki-67+, GFAP+, p53-, EGFR+

A

Glioblastoma

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8
Q

Rosenthal fibers

A

pilocytic astrocytoma

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9
Q

Chicken wire / fried egg

A

Oligodendroglioma

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10
Q

1p19q LOH

A

oligodendroglioma

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11
Q

EGFR amplification (chromosome 10)

A

Primary GBM

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12
Q

IDH1/2

A

Secondary GBM

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13
Q

Pseudorosettes

A

Ependymomas

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14
Q

Blue cell tumors

A

Medulloblastomas

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15
Q

Sugar icing appearance

A

Medulloblastomas

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16
Q

Whorls & cords of epithelial-like cells

A

Meningiomas

17
Q
A

Pseudorosettes (ependymomas)

18
Q
A

Pilocytic Astrocytoma

19
Q
A

Pilocytic Astrocytoma

20
Q
A

Eosinophilic Granular Bodies (PA)

21
Q
A

Pseudopalisading Necrosis (GBM)

22
Q
A

GBM Anaplasia

23
Q
A

Microvascular Proliferation (GBM)

24
Q
A

Oligodendroglioma (Fried Egg / Chicken Wire)

25
Q
A

Medulloblastoma

26
Q
A

Medulloblastoma

27
Q
A

Meningioma (Whorls & Cords of epithelial-like cells)

28
Q
A

Schwannoma

29
Q

What is the difference between a Schwannoma and a Neurofibroma?

A

Neurofibromas incorporate axons; Schwannomas push existing neural structures to the side.

30
Q

Patients with NF2 are the ONLY type of patients to have what kind of bilateral tumor?

A

Bilateral acoustic/vestibular Schwannoma

31
Q

Schwannoma v. Neurofibroma: NF1 or NF2?

A

NF1: Neurofibroma

NF2: Schwannoma

32
Q

Meningioma Epidemiology

A

F > M

Up to 50% of patients with NF2

33
Q

Tumors seen in patients with NF2?

A

Schwannomas, Meningiomas

34
Q
A

Rosenthal Fibers (PA)

35
Q
A

Neurofibroma (long segment)

Brain and Behavior II (3 decks)

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