DRUGS Flashcards
What is propanolol?
Generalised beta-antagonist; best we have for beta2s but not clinically useful
What is salbutamol?
A beta2 agonist. it is specific and usually used to treat asthma
What is clonidine?
An alpha2 agonist. Used to inhibit SNS transmission e.g sedation.
What is yohimbine?
An alpha2 antagonist. Used to reverse effects of clonidine
What is isoprenaline?
A general beta-adrenoceptor agonist. Not good for asthma as increases HR too much
What is atenolol?
A specific beta1 antagonist - slows HR - used for hypertension
What is dobutamine?
A specific beta1 agonist - increases HR - use in heart failure
What is phenylephrine?
A specific alpha1 agonist - used as a decongestant
What is phentolamine?
A non-specific alpha-adrenoceptor antagonist
What is prazosin?
A specific alpha-1 antagonist - useful in hypertension though risk of large fluctuations in blood pressure when change posture, causing dizziness and fainting
What are two drugs that inhibit NA uptake by presynaptic neuron?
Cocaine, desipramine
What is an example of a MAO blocker?
Moclobemide
What is are two examples of indirectly acting sympathomimetics?
Amphetamine, ephedrine
What are two muscarinic AChR antagonists?
Atropine, hyoscine, ipratopium
What are three muscarinic AChR agonists?
pilocarpine, carbachol, bethanecol
What are two therapeutic anticholinesterases?
Physostigmine
Neostigmine
What are some nAChR antagonists?
NMJ
- vecuronium, d tubocurare (non-depolarising)
- suxamethonium (depolarising)
Ganglion - hexamethonium
nAChR agonist?
Nicotine
What does icatibant do?
Antagonist at bradykinin R
What do NSAIDs do? example?
Aspirin
- inhibit COX
- reduce PG synthesis > PG and BK dont surmount
What do glucocorticoids do? Example?
Dexamethosone
- Inhibit PLA2
- Inhibit COX
- inhibit cytokine formation
- inhibit adhesion molecule expression
Which drug is an example of a generalised alpha adrenoceptor antagonist?
Phentolamine
Which drug is an example of a generalised beta adrenoceptor antagonist?
Propanolol
Which drug is an example of a generalised beta adrenoceptor agonst?
Isoprenaline
Which drug is an example of a specific alpha1 agonist?
Phenylephrine - decongestant
Which drug is an example of a specific alpha1 antagonist?
Prazosin - hypertension
Which drug is an example of a specific beta1 agonist?
Dobutamine - heart failure
Which drug is an example of a specific beta1 antagonist?
Atenolol - hypertension
Which drug is an example of a specific beta2 agonist?
Salbutamol
Which drug is the best we have for beta2 antagonist?
Propanolol
Which is drug is a generalised agonist for beta adrenoceptors?
Isoprenaline
Which drug would you give for prolonging NA effects - slow onset?
Moclobamide
Which drug would you give for prolonging NA effects - fast onset?
Desipramine
What is amphetamine?
An indirectly acting sympathomimetic
What is carbachol?
A mAChR agonist
What is pilocarpine?
A mAChR agonist
