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Cells to systems > DRUGS > Flashcards

DRUGS Flashcards

1
Q

What is propanolol?

A

Generalised beta-antagonist; best we have for beta2s but not clinically useful

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2
Q

What is salbutamol?

A

A beta2 agonist. it is specific and usually used to treat asthma

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3
Q

What is clonidine?

A

An alpha2 agonist. Used to inhibit SNS transmission e.g sedation.

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4
Q

What is yohimbine?

A

An alpha2 antagonist. Used to reverse effects of clonidine

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5
Q

What is isoprenaline?

A

A general beta-adrenoceptor agonist. Not good for asthma as increases HR too much

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6
Q

What is atenolol?

A

A specific beta1 antagonist - slows HR - used for hypertension

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7
Q

What is dobutamine?

A

A specific beta1 agonist - increases HR - use in heart failure

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8
Q

What is phenylephrine?

A

A specific alpha1 agonist - used as a decongestant

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9
Q

What is phentolamine?

A

A non-specific alpha-adrenoceptor antagonist

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10
Q

What is prazosin?

A

A specific alpha-1 antagonist - useful in hypertension though risk of large fluctuations in blood pressure when change posture, causing dizziness and fainting

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11
Q

What are two drugs that inhibit NA uptake by presynaptic neuron?

A

Cocaine, desipramine

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12
Q

What is an example of a MAO blocker?

A

Moclobemide

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13
Q

What is are two examples of indirectly acting sympathomimetics?

A

Amphetamine, ephedrine

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14
Q

What are two muscarinic AChR antagonists?

A

Atropine, hyoscine, ipratopium

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15
Q

What are three muscarinic AChR agonists?

A

pilocarpine, carbachol, bethanecol

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16
Q

What are two therapeutic anticholinesterases?

A

Physostigmine

Neostigmine

17
Q

What are some nAChR antagonists?

A

NMJ
- vecuronium, d tubocurare (non-depolarising)
- suxamethonium (depolarising)
Ganglion - hexamethonium

18
Q

nAChR agonist?

A

Nicotine

19
Q

What does icatibant do?

A

Antagonist at bradykinin R

20
Q

What do NSAIDs do? example?

A

Aspirin

  • inhibit COX
  • reduce PG synthesis > PG and BK dont surmount
21
Q

What do glucocorticoids do? Example?

A

Dexamethosone

  • Inhibit PLA2
  • Inhibit COX
  • inhibit cytokine formation
  • inhibit adhesion molecule expression
22
Q

Which drug is an example of a generalised alpha adrenoceptor antagonist?

A

Phentolamine

23
Q

Which drug is an example of a generalised beta adrenoceptor antagonist?

A

Propanolol

24
Q

Which drug is an example of a generalised beta adrenoceptor agonst?

A

Isoprenaline

25
Q

Which drug is an example of a specific alpha1 agonist?

A

Phenylephrine - decongestant

26
Q

Which drug is an example of a specific alpha1 antagonist?

A

Prazosin - hypertension

27
Q

Which drug is an example of a specific beta1 agonist?

A

Dobutamine - heart failure

28
Q

Which drug is an example of a specific beta1 antagonist?

A

Atenolol - hypertension

29
Q

Which drug is an example of a specific beta2 agonist?

A

Salbutamol

30
Q

Which drug is the best we have for beta2 antagonist?

A

Propanolol

31
Q

Which is drug is a generalised agonist for beta adrenoceptors?

A

Isoprenaline

32
Q

Which drug would you give for prolonging NA effects - slow onset?

A

Moclobamide

33
Q

Which drug would you give for prolonging NA effects - fast onset?

A

Desipramine

34
Q

What is amphetamine?

A

An indirectly acting sympathomimetic

35
Q

What is carbachol?

A

A mAChR agonist

36
Q

What is pilocarpine?

A

A mAChR agonist

Cells to systems (4 decks)

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