Drugs

Question 1

How do antipsychotics work?

Answer 1

Block postsynaptic D2 and serotonin 2A

Question 2

How do antidepressants work?

Answer 2

Increase synaptic norepi and serotonin through inhibition of reuptake mechanisms

Question 3

What drug treats mania?

Answer 3

Lithium

Question 4

What drug class treats anxiety?

Answer 4

Benzodiazepines

Question 5

How do benzodiazepines work?

Answer 5

Activate binding sites on teh GABA receptor -> hyperpolarization of the neuronal membrane and decreased neuronal firing

Question 6

How is norepinephrine made?

Answer 6

Beta-hydroxylase converts dopamine into norepi.

Question 7

What is norepi involved in?

Answer 7

Mood
Anxiety
Arousal
Learning
Memory

Question 8

What is serotonin involved in?

Answer 8

Mood
Sleep
Pain sensitivity
Appetite
Sexuality
Impulse control

Question 9

What is glutamate involved in?

Answer 9

Epilepsy,
Neurodegenerative diseases
Memory formation
Schizophrenia (NMDA receptor dysfunction)

Question 10

Which 2 amines are involved in the negative side effects on antipsychotic meds?

Answer 10

ACh and histamine

Question 11

How is serotonin made?

Answer 11

Tryptophan is converted to serotonin by tryptophan hydroxylase