Drugs

Question 1

emollients e.g. aqueous cream, ointment, liquid/white soft paraffin

‘dermobase’ ‘doublebase’

Answer 1

used for dry skin: rehydrate + surface lipid layer

SE: irritant/allergic (preservatives/perfumes

Question 2

topic steroids - potencies

Answer 2

mild: hydrocortisone (1%, 2.5%);
synalar 1in10; Canasten/Daktacort/Fucidin combo

moderate: Eumovate (clobetosone), Betnovate (1in4 betamethasone), Sticdex; Trimovate combo
potent: Propaderm, Betnovate, Elocon, Synalar, Diprosone; Fucibet, Betnovate-C combo

very potent: Dermovate (clobetasol), Nedsone forte; Dermovate-NN combo

PO: prednisolone/prednisone

Question 3

topical steroids

fingertip units
short courses esp. sensitive areas
weaning and breaks

Answer 3

anti-inflammatory and anti-proliferative

used for: allergy/immune rxn, inflammation (acne, eczema, psoriasis), blistering, CTD, vasculitis

Question 4

oral aciclovir

Answer 4

used for: viral infectiosn (HSV/VZV)

SE: GI upset, LFTs, neuro (reversible), haematological

Question 5

oral antihistamines

sedative: chlorpheniramine, hydroxyzine
non-sed: certrizine, loratidine

Answer 5

Used for: TI hypersensitivity (urticaria), eczema; reduce itching

SE: sedationa, anti-ACh (blurry vision, dry mouth, retention, constipation)

Question 6

topical/oral ABx

top: fisidic acid, mupirocin (Bactroban), neomycin
PO: pens, cephs, gent, macrolides, nitrofurantoin, quino, tetracyclines, vanco, metronidazole, trimethoprim

Answer 6

bacterial skin infections
can use some for acne (tetracyclines)

SE: local irritation/allergy; GI upset, rash, anaphylaxis, vaginal candidiasis, Ab-associated infection/dd (C. diff), resistance (esp. fusidic - rapid)

Question 7

topical antiseptics

Answer 7

treat and prevent infection
SE: irritation/allergy

chlorhexidine, cetrimide, povidone-iodine

Question 8

oral retinoids

Answer 8

isotreninoin, acitretin
used for: acne, psoriasis, keratin disorders

SE:

• mucocutaneous rxn: dry skin/lips/eyes
• LFT, hypercholesterolaemia, hyperlipidaemia (TAG)
• myalgia, arthalgia
• ?depression
• teratogenic: double contraception, monthly preggo tests until 1/12 after iso, 2 years after acitretin

Question 9

topical retinoids

Answer 9

ADD!!!

Question 10

topical steroids - SE

Answer 10

local: skin atrophy, telangiectasia, striae, infections (mask/worse), acne, perioral dermatitis, allergic contact dermatitis
systemic: Cushing’s, immunosuppression, HTN, DM, osteoporosis, cataracts, psychosis