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MCQ knowledge > Drugs > Flashcards

Drugs Flashcards

1
Q

T/F: esomeprazole causes constipation

A

False - it causes diarrhoea

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2
Q

Many cells produce TNF-alpha during an acute phase reaction leading to systemic inflammation.

Which of these is the main one?

Name the others (6).

A

TNF-alpha produced chiefly by activate ‘macrophages’.

Others include:

  • CD4+ T-cells
  • NK cells
  • Neutrophils
  • Mast cells
  • Eosinophils
  • Neurons.
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3
Q

TNF-alpha has a multitude of effects on multiple cells. What are the effects on the following 3 immune cells:

  1. T-cell
  2. B-cell
  3. Monocyte
A
  1. T-cell: promotes T-cell proliferation
  2. B-cell: promotes Ab formation
  3. Monocyte: increases differentiation
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4
Q

Name 5 TNF-inhibitors.

Who is the odd-one-out in terms of MOA?

A 
Adalimumab
Certolizumab
Etanercept
Golimumab
Infliximab
  • Etanercept is a soluble TNF receptor
  • The rest are recombinant monoclonal Ab that bind TNF.
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5
Q

What 4 rheumatological conditions are TNF-inhibitors indicated in?

A
  1. RA
  2. Psoriatic arthritis
  3. Ankylosing Spondylitis
  4. Juvenile Idiopathic Arthritis
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6
Q

Which gastroenterological conditions are TNF-inhibitors indicated?

A

IBD: UC and CD

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7
Q

Which skin disorder and vascular disease is TNF-inhibitors indicated?

A

Skin - Psoriasis

Vascular - Giant cell arteritis

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8
Q

What is the function of IL-6?

A
  • Mediator of fever and acute phase reaction

- Has both pro-inflammatory cytokine and anti-inflammatory myokine (cytokine released by muscle)

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9
Q

Name 3 IL-6 inhibitors.

How do they differ in MOA?

A

mAb to IL-6 receptor: Tocilizumab, Sarilumab

mAB to IL-6: Sirukumab

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10
Q

Which 3 conditions are IL-6 inhibitors indicated?

A
  1. RA
  2. Giant cell arteritis
  3. Juvenile idiopathic arthritis
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11
Q

Which one condition is IL-6 inhibitor use a possibility?

A

SLE - trials underway with positive results

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12
Q

What is the function of IL-1?

A

Pro-inflammatory cytokine.

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13
Q

Which 5 immune cells does IL-1 beta affect?

A
  1. Np
  2. Monocytes
  3. T-cells (Th17/T-alpha/gamma)
  4. ILC3 (innate lymphoid cell type 3)
  5. Osteoclasts
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14
Q

What is the effect of IL-1 beta on the following organ systems:

  1. Cartilage
  2. Bone
  3. Blood vessels
  4. Hypothalamus
  5. Pancreas
A
  1. Cartilage - matrix enzyme production causing damage
  2. Bone - osteoclast activation leading to bone loss
  3. Blood vessels - intimal inflammation leading to atherogenesis
  4. Hypothalamus - fever and pain response
  5. Pancreas - beta-cell apoptosis leading to DM
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15
Q

What are 3 IL-1 inhibitors?

What are the MOA?

A
  1. Anakinra: IL-1 receptor antagonist
  2. Rilonacept: soluble decoy receptor that bind IL-1
  3. Canakinumab: anti-IL-1-beta mAB
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16
Q

What are 3 anti-IL-1 inhibitors?

A
  1. Anakinra: IL-1 receptor antagonist
  2. Rilonacept: soluble decoy receptor that bind IL-1
  3. Canakinumab: anti-IL-1-beta mAB
17
Q

Which 3 conditions are IL-1 inhibitors indicated?

A
  1. Rheumatoid arthritis
  2. Gout
  3. Juvenile Idiopathic Arthritis
18
Q

What are the 2 [IL-12 / IL-23] inhibitors?

A

Ustekinumab and Briakinumab - both mAb to IL-12/IL-13

19
Q

What 2 conditions are [IL-12 / IL-23] inhibitors indicated?

A
  1. Psoriasis

2. Psoriatic arthritis

20
Q

What are the 3 IL-17A inhibitors?

A

BIS:

Brodalumab
Ixekizumab
Secukinumab

21
Q

What 3 conditions are IL-17A inhibitors indicated?

A

PPA:

Psoriasis
Psoriatic arthritis
Ankylosing spondylitis

22
Q

Name 3 anti-CD20 agents.

A

ROO:

Rituximab
Ofatummumab
Ocrelizumab

23
Q

What 4 conditions are treated by anti-CD20 agents?

A

RRAP

RA (rheumatoid arthritis)
RRMS (relapsing remitting multiple sclerosis)
AAV (ANCA-associated vasculitis)
PPMS (primary progressive multiple sclerosis)

24
Q

Name 2 anti-BAFF agents.

A

TB:

Tabalumab
Belimumab

25
Q

Which 1 condition is treated with anti-BAFF agents?

A

SLE

26
Q

What are the 2 CTLA4-Ig (fusion protein) agents?

A

BA:

Belatacept
Abatacept

27
Q

What condition is CTLA4-Ig (fusion protein) agents indicated in?

A

RA (Rheumatoid Arthritis)

MCQ knowledge (22 decks)

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