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Biochemistry 2 > Drugs > Flashcards

Drugs Flashcards

1
Q

Fluorouracil (5-FU)

A

blocks dUMP -> dTMP

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2
Q

Methotrexate

A

inhibits dihydrofolate reductase

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3
Q

Zidovudine

A

mimics nucleotides, inhibits synthesis, doesn’t have a free 3’ OH

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4
Q

Azithromycin

A

binds 50S, inhibits translation

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5
Q

Ciprofloxacin

A

inhibits DNA gyrase

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6
Q

Actinomycin D

A

too toxic for clinical use

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7
Q

Rifampicin

A

inhibits transcription initiation

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8
Q

Streptolydigin

A

inhibits message elongation

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9
Q

a-amanitin

A

inhibits euk RNA pol II - prevent transcription

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10
Q

Streptomycin

A

binds 16S of 30S - inhibits initiation

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11
Q

Tetracycline

A

binds 30S - inhibits binding at A site

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12
Q

Chlorophenicol

A

binds 50S - blocks tRNA - bad for humans because it’s similar to 55S mitochondrial ribosome

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13
Q

Erythromycin

A

binds 50S - blocks translocation

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Biochemistry 2 (3 decks)

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