Drugs

Question 0

Intrisic pathway factors ccan be affected by what?

Answer 0

Activated partial thrombolplastin time (KCCT).

Unfractionated heparni

Question 1

What are factors in the extrinsice coag pathway dependdent on? How are they measured?

Answer 1

VItamin K

INR

Question 2

What does fibrinogen?

Answer 2

Crooss links platelets

Question 3

How does clopidogrel act?

Answer 3

P2Y12 inhibitor

Question 4

How doe dypryridamole act?

Answer 4

Blocks cAMP in platelelet??

Question 5

How does tirofiban act?

Answer 5

On IIb/IIIa receptor

Question 6

How do thrombi in venous system differ from arterial thombi?

Colour, content and treatent

Answer 6

Red vs white
Fibrin rich vs platelet rich
Heparin/warfarin vs antiplatelet agentsmain use of antiplatelet agens?

Question 7

Main use of antiplatelets?

Answer 7

CV events
Primary (not recommended) and secondary prevention (well established)
Acute treatment (established)

Question 8

What is rate of GI haem/ulcer perforation when apsirin iis used

Answer 8

0.1-0.5% per annum (?check?)

Question 9

SSide effects of asthma? (2, not bleeding)

Answer 9

Asthma

Hyperuricaeemia

Question 10

Which antiplatelet drug is a PRO drug? Why is this signif?

Answer 10

Clopidogrel. You should not give omeprazole because stops C proteins form metabolising clopidogrel and activating, give H2 antag instead

Question 11

What is most widely used anti-coag drug?

Answer 11

Warfarin

Question 12

how does warfarin work?

Answer 12

Inhibits vit K dep caraboxylation of factors II, VII, IX, X

Question 13

What is the hlaf life of wararin?

Answer 13

Long

Question 14

Wheen is warfarin used?

Answer 14

Venous thrombo event.

Question 15

1st VT event, how long on warfarin? 2nd? INR targets?

Answer 15

6 months
Lifelong
2.5 for both

Question 16

What do you do wwith warfarin after DVt on warfarin?

Answer 16

Incr INR (sometiimes) to 3.5

Question 17

How long do you take warfarin for when you are preparing for aF peri-cardioversion? Why?

Answer 17

6w before and after. Atria may not starrt to pump propery for a few weeks so there is still clot risk.

Question 18

WHat is INR target for lifelong warfarin for lifelong AF?

Answer 18

2.5

Question 19

Mechanical valcve warfarin, what is INR target?

Answer 19

2.75 (?)

Question 20

What are the absolute CIs for warfarin? (5)

Answer 20

Active bleeding
Bleeding disorder
1st trimester of pregnancy
Space occupying lesion of CNS
Recent surgeery

Question 21

What are teh imoortnat interactions (pharm) of warfarin

Answer 21

drugs

Question 22

Compare unfractionated vs LMW hepararin
Clinical use
Admin
Dose
Dose monitoring
Monitoring metthod
Reversal
Adverse effects
.....

Answer 22

dsgsjgsjgklj

Question 23

Clinical uses of heparins

Answer 23

Pregnancy
…
Bridging anti-coag - mech valve patients undergoing non-cardiac surgery

Question 24

3 settings for the use of thrombolytics

Answer 24

STEMI (PCI not available)
Stroke (within 3 hrs)
Major PE (very exceptional circumstances)

Question 25

What is biggest factor affecting whether thrombolysis for STEMI is affective

Answer 25

Time given

Question 26

Up until what point would you consider thrombolysis in a STEMI?

Answer 26

12 hours