Drugs

Question 1

colchicine

Answer 1

ACUTE GOUT, unknown MOA; side fx- diarrhea, RARE myopathy, RARE bone marrow suppression

Question 2

allopurinol

Answer 2

CHRONIC GOUT, xanthine oxidase inhibitor; allopurinol hypersensitivity reaction

Question 3

febuxostat

Answer 3

CHRONIC GOUT, xanthine oxidase inhibitor; indicated for pts w/ allopurinol hypersensitivity reaction

Question 4

probenicid

Answer 4

uricosuric, targets URAT1 to increase excretion

Question 5

rasburicase

Answer 5

uricase replacement; cannot be used repeatedly

Question 6

methotrexate

Answer 6

disease-modifying agent; MOA unclear; contraindicated w/ alcohol use; indicated for JIA, rheumatoid arthritis

Question 7

etanercept

Answer 7

soluble TNF-receptor coupled to Fc portion of IgG; indicated for rheumatoid arthritis (2nd line due to $); risk of TB recurrence

Question 8

infliximab

Answer 8

anti-TNF; indicated for rheumatoid arthritis (2nd line due to $); risk of TB recurrence

Question 9

tocilizumab

Answer 9

IL-6 receptor; similar effects as anti-TNF

Question 10

tofacitinib

Answer 10

JAK3 kinase inhibitor; indicated for rheumatoid arthritis (novel agent)

Question 11

abatecept

Answer 11

CTLA-4 Ig interferes w/costimulation signal for T-cell activation; equivalent efficacy to anti-TNF; side fx- infections, dyslipidemia