Auto-Antibodies Flashcards
1
Q
anti-dsDNA
A
50-75% specific for SLE
2
Q
anti-Ro
A
95% specific for SLE, Sjogren’s
3
Q
anti-SM
A
30% specific for SLE
4
Q
anti-U1RNP (spliceosome)
A
mixed connective tissue disease
5
Q
anti-histone
A
90% specific for drug lupus (ex: hydralazine)
6
Q
rheumatoid factor
A
IgM against Fc of IgG; 85% specific for rheumatoid arthritis
7
Q
anti-citrullinated protein antibody (APCA)
A
Agn –PADI–> Citrulline (neutral); HIGHLY specific for rheumatoid arthritis