Drugs

Question 1

brimonidine

Answer 1

adrenergic agonist, catecholamine
alpha 2 selective
decrease BP and HR, causes vasoconstriction
hypertension

Question 2

clonidine

Answer 2

adrenergic agonist, catecholamine
alpha 2 selective
decrease Bp and HR, doesn’t cause vasoconstriciton
dry mouth, dedation, impotence, withdrawal, dramatic rebound HTN when stopped suddenly
hypertension

Question 3

isoproterenol

Answer 3

beta adrenergic agonist, catecholamine
non selective
stimulation of autonomic receptors
cardiovascular, asthma

Question 4

epinephrine/norepineprine

Answer 4

adrenergic agonsit, endogenous ligand, catecholamine
non selective
epi works on beta 2, NE doesn’t so safe for heart contractive w/o relaxation of lungs
heart and lungs; NE: ADHD, depression

Question 5

tetrahydrolozine

Answer 5

adrenergic agonist, noncatecholamine
alpha agonist
constricts BV o reduce red eye

Question 6

phenylephrine/pseudoephedrine

Answer 6

adrenergice agonist, noncatecholamine
alpha 2 agonist
decongestant, stimulation of automonic receptors, alpha and beta stimulation

Question 7

albuterol

Answer 7

adrenergic agonist, noncatecholamine
beta2 agonist
smooth muscle relaxation in lungs-bronchodialtion
asthma and COPD treatment

Question 8

imipramine

Answer 8

• tricyclic antidepressant/adrenergic reuptake inhibitor
• block reuptake transporter (amine uptake pump) on pre synaptic cell and prevents NE from being taken from synaptic space and brought to pre-syn
• effect on neurons, not so much muscles

Question 9

prazosin

Answer 9

• tamusolin in elderly men
• alpha-adrenergic antagonist
• alpha 1 selective (blocker), sympathoplegic, acts on arterioles
• adrenoreceptor blocker, prevents contraction, blockage of autonomic receptors (alpha), dilate vessels and blocs sympathetic system
• mild tachycardia (abnormal heartrate), reduced sympathetic tone
• benign prostate hyperplasia (prevent urine), mild HT as monotherapy, mod/sev HT (beta1 combo therapy)

Question 10

propanolol

Answer 10

• beta-adrenergic antagonist
• non selective, beta blocker
• contracts bronchia smooth muscle, relaxes heart, decrease HR and BP, blocakde of automonic receptors
• orthostatic hypotension, tachycardia, HA
• glaucoma, silent angia, acute coronary syndrome, cardiac arrhythmia

Question 11

labetalol

Answer 11

alpha 1 and beta adrenergic antagonist

• non selective, sympathaloplegic
• adrenoreceptor blocker, prevents contraction, blocks alpha1 receptor
• moderate toxicity, asthma, bradycardia, heart failure
• mild HT as monotherapy, mod/sev HT (beta 1-combo therapy)

Question 12

atenolol (metaprolol)

Answer 12

beta-adrenergic antagonist

• beta 1 selective beta blocker
• reduction in BP, reduction in cardiac work
• orthostatic hypotension, tachycardia, HA,
• silent angia, acute coronary syndrome, cardiac arrhythmia