Drugs

Question 1

Side effects of cholinergic nervous system (excessive muscarinic discharge)

Answer 1

Salivation
Lacrimation
Urination
Defecation
Gastro upset, including diarrhea
Emesis/eye myosis

Question 2

Two types of Neuromuscular blocking agents

Answer 2

depolarizing and non-depolarizing agents

Question 3

MOA of non depolarizing agents (NMJ blockers)

Answer 3

Curare derivatives, they reversibly block Nm cholinergic receptors, preventing channel opening and membrane depolarization

Question 4

How can non depolarizing NMJ blocking agents be reversed?

Answer 4

AChEIs, to increase the amount of ACh and overcome the competitive block

Question 5

Name three nondeoplarizing NMJ blocking agents

Answer 5

Tubocurarine
Rocuronium
Atracurium

Question 6

MOA of Succinylcholine

Answer 6

SuCh binds to Nm cholinergic receptors are initially stimulates them, causing muscle fasiculations. It results in prolonged depolarization

Question 7

Name two direct cholinergic agnonists

Answer 7

Pilocarpine, Bethenachol

Question 8

Indirect cholinergic agnonists are what kind of drugs?

Answer 8

Acetylcholinesterase inhibitors

Question 9

Short-medium acting reversible AChEIs

Answer 9

Edrophonium, Donepezil

Question 10

medium-long acting reversible AChEIs

Answer 10

Neostigmine, pyridostigmine

Question 11

Irreversible cholinergic agonists

Answer 11

organophosphate nerve gases

Question 12

Name 4 direct cholinergic antagonists

Answer 12

Atropine-Scopolamine

Oxybutynin, Tolterodine

Question 13

What is the MOA of indirect cholinergic antagonists

Answer 13

paralysis, either through prolonged depolarization (succinylcholine), or through competitive blocking of the Nm receptor (Tubocurarine, rocuronium, Atracurium)

Question 14

Side effects of anticholinergics

Answer 14

Can’t see, can’t spit, can’t pee, can’t shit