Drugs Flashcards
1
Q
Anti-inflammatory Cytokine inhibitors (specifically TNF-a inhibitor) used to treat chronic inflammatory disease
A
Etanercept, Infliximab
2
Q
Anti-inflammatory Type of NSAID, irreversibly inhibits COX
A
Aspirin
3
Q
Anti-inflammatory Probably the most widely used medication worldwide, Inhibits COX
A
NSAID
4
Q
Inhibitor of 5-lipoxygenase, inhibits cys-LTs (bronchoconstriction and increase vascular permeability) AND LTB4 (chemotaxis) Prophylactic treatment of mild asthma
A
Zileuton
5
Q
Cys-leukotriene receptor antagonist Prophylactic treatment of mild asthma
A
Zafirlukast
6
Q
Anti-inflammatory Glucocorticoids, bind to cytoplasmic receptors, that localize to nucleus and bind DNA
A
Steroid
7
Q
PGE2 analog cervical ripening in pregnancy terminate early pregnancy
A
Dinoprostone
8
Q
PGF2 analog Termination of pregnancy in 2nd trimester Control postpartum hemorrhage
A
Carboprost
9
Q
PGE1 analog Prevention of ulcers with long-term NSAID use
A
Misoprostol
10
Q
PGE1 analog tx: Impotence/erectile dysfunction Maintenance of patent ductus arteriosus
A
Alprostadil
11
Q
PGI2 analog tx: Primary pulmonary hypertension
A
Epoprostenol
12
Q
PGF2 analog tx: Glaucoma Eyelash hypotrichosis
A
Bimatoprost
13
Q
SE for Dinoprostone
A
GI-related, fever, uterine rupture, contraindicated in women with hx of C-section
14
Q
SE for Carboprost
A
GI related, fever, uterine rupture, rare cases-bronchoconstriction
15
Q
SE for Misoprostol
A
Diarrhea common, contraindicated in pregnancy
16
Q
SE for Alprostadil
A
Pain at site of injection, Priapism Apnea in neonates
17
Q
SE for Epoprostenol
A
nausea, vomiting, headache, flushing
18
Q
SE for Bimatoprost
A
eye redness, itching, permanent change in eye color, excess hair growth
19
Q
Synthesis controlled by Angiotensin II and plasma K+ Steroid drug
A
Aldosterone
20
Q
Synthesis controlled by ACTH Steroid drug Anti-inflammatory potency = 1
A
Cortisol
21
Q
Steroid drug Anti-inflammatory potency = 20
A
Dexamethasone
22
Q
Corticosteroid drug Used to treat allograft rejection, always in combination Anti-inflammatory potency = 3
A
Prednisolone
23
Q
Steroid drug Anti-inflammatory potency = 12
A
Fludrocortisone
24
Q
Inhibits synthesis of cortisol Blocks 11-beta hydroxylation – synthesis stops at 11-deoxycortisol Plasma ACTH levels increase Stimulates synthesis and excretion of 17-hydroxycorticoids as 11-deoxycortisol
A
Metyrapone
25
Competitive antagonist at progesterone and glucocorticoid receptor Used to terminate pregnancy and to treat Cushing Diease
Mifepristone
26
Competitive antagonists at mineralcorticoid receptor Diuretics Treat hypertension, Cardiac hypertrophy and heart failure
Spirinolactone, Eplerenone
27
Progesterone receptor agonist Used with estrogen to suppress ovulation, or as hormone replace for post-menopausal women Mineralcoricoid receptor antagonist-- diuretic, antagonizes salt retention effects of estrogen Androgen receptor antagonist
Drospirenone
28
Main contraindication for using steroid drugs
Existing infection, especially TB
29
Metabolized to 6-mercaptopurine Inhibits purine biosynthesis-- inhibits de novo and salvage pathways of DNA synthesis Used to inhibit transplant rejection and in RA SE: Bone marrow despression
Azathioprine
30
Alkylating agent that cross-links DNA Toxic effect more pronounced in B cells Used to treat autoimmune diseases in combo with other drugs SE: Bone marrow depression
Cyclophosphamide
31
Inhibitor of dihydrofolate reductate --\> inhibits folate dependent steps in purine synthesis --\> inhibits DNA synthesis Used to treat autoimmune diseases SE: hepatotoxicity
Methotrexate
32
Lymphocyte selective immunosuppressant Used with cyclosporine and corticosteroids to prevent renal allograft rejection Used to treat autoimmune diseases (RA and psoriasis) Contraindicated in: GI disease, reduced renal function, infections and pregnancy
Mycophenolate Mofetil
33
Lipophilic peptide antibiotic Inhibits mRNA synthesis that codes for lymphokines like IL-2 --\> inhibits T cell proliferation and cytotoxicity Used to prevent rejection of transplanted organs SE: nephrotoxicity
Cyclosporine
34
Binds FK binding protein Same spectrum of action as cyclosporine but 50-100x more potent Used to prevent rejection of transplanted organs Less nephro- and hepatotoxicity
Tacrolimus
35
Inhibits T cell activation and proliferation downstream of IL-2 Binds FKBP-12 --\> inhibits mTOR, blocks G1 -\> S transition Used to prevent rejection of transplanted organs
Sirolimus
36
organic nitrate, venous dominant, tx heart failure, SE hypotension
Nitroglycerine
37
NO releasing, arterial & venous, tx hypertensive emergencies, SE hypotension
Nitroprusside
38
direct vasodilator, tx heart failure (with isosorbide dinitrate), tx severe HTN and emergencies, arterial dominant
Hydralazine
39
direct vasodilator, severe HTN, ATP-channel opener, arterial dominant, SE fluid retention (used with diuretics)
Minoxidil
40
membrane channel dilator, K+ channel opener, tx HTN emergencies, SE hypoglycemia
Diazoxide
41
membrane channel dilator, CCB, non-selective, arterial dominant
Dihydropyridines (Nifedipine), Phenylalkylamine (Verapamil), Benzothiazapine (Diltiazem)
42
PDE3 inhibitors (tx heart failure, intracellular signaling), increase cAMP
Milrinone, Inamrinone, Cilostazol
43
PDE5 inhibitors (tx ED), increase cGMP
Sildenafil, Tadalafil
44
Renin-Angiotensin Inhibitors
ACE inhibitors
45
decrease Ang II, increase bradykinin
ACE inhibitors
46
D1 receptor, arterial and venous, increase renal blood flow and Na excretion, tx HTN crisis
Fenoldopam
47
Alpha-adrenergic blocker, arterial and venous circulation
Prazosin
48
B2 adrenergic agonists bronchodilators, increase cAMP/PKa, SE tachycardia
Albuterol, Pirbuterol, Terbutaline, Salmeterol, Formoterol
49
anti-cholinergic bronchodilators, act on muscarinic receptors, decrease mucous secretion
Ipratropium, Tiotropium
50
methylxanthine bronchodilators, adenosine receptor antagonists
Theophylline, Aminophylline
51
serotonin agonist, relatively non-specific, 5HT2, potent hallucinogen
LSD (lysergic acid diethylamide)
52
5HT1A receptor partial agonist, antianxiety
Buspirone
53
5HT1D, vasoconstriction, tx migraines, inhibit release of CGRP (vasoactive peptide), SE? CI?
Sumatriptan nausea, vomiting, angina, dizziness and flushing, CI = recent MI
54
SSRI, tx affective disorders, OCD, panic attacks. SE?
Fluoxetine SE = sexual dysfunction, nausea, sleep disorders
55
MAOI, tx affective disorders, narcolepsy. SE?
Phenelzine. SE = HTN crisis
56
Serotonin antagonist, 5HT2, H1 antagonist, tx: allergies, puritis, urticaria, carcinoid syndrome
Cyproheptadine
57
5HT3 antagonist, tx chemo-induced nausea/vomiting, post-op/x-ray-induced nausea/vomiting, CNS and GI action
Ondansetron
58
5HT3 antagonist, diarrhea-predominant IBS in women, SE = severe GI adverse effects
Alosetron
59
para-aminophenol derivative; no affinity for active site of COX (may have increased selectivity for brain COX); oral admin; metabolism by glucoronidation and sulfation, also CYP 2E1; renal excretion; tx: acute pain and fever, NO anti-inflammatory effects SE: hepatic toxicity
acetaminophen
60
irreversible inhibitor of COX 1&2
acetylsalicylic acid
61
oral absorption, crosses BBB and placenta, dose-dependent half-life, renal elimination, uricosuric
aspirin
62
selective COX-2 inhibitor; CYP 2C9 metabolism; tx: RA/osteoarthritis, dysmenorrhea, acute pain, colorectal polyps SE? CI?
celecoxib SE: hypersensitivity, increase risk of GI irritation/bleeding/ulceration, MI, anemia CI: sulfonamide toxicity, NSAID hypersensitivity, CV risk factors, history of GI bleeding, 2C9 deficiency
63
pyrrole derivative; reversible inhibitor of COX 1&2; oral, IV & IM; alternative for opioid analgesics in treating post-op pain (\>inflammation) SE: serious adverse GI, renal fx, bleeding and hypersensitivity
ketorolac
64
reversible inhibition of COX 1&2, 3-4x/day tx: inflammatory diseases, rheumatoid disorders, fever, dysmenorrhea, osteoarthritis, IV form used to induce closure of PDA
ibuprofen
65
reversible inhibition of COX 1&2, oral & IV, 35-50% have adverse effects tx: gout, close PDA, not pain/fever
indomethacin
66
reversible, non-selective; pro-drug; oral admin (1x/day); active metabolite may be more COX-2 specific; tx: manage osteoarthritis and RA
nabumetone
67
reversible inhibition of COX 1&2, once/day tx: ankylosing spondylitis, osteoarthritis, acute gout, rheumatoid disorders, fever, dysmenorrhea
naproxen
68
salicylate; effect independent of COX inhibition: inhibit cytokine production and lipoxygenase, free radical scavenger; tx: ulcerative colitis, RA; sulfa moiety = high % adverse effects
sulfasalazine
69
reversible, non-selective; oral admin (1x/day); long half-life, CYP 2C9 metabolism; tx: acute and chronic RA/osteoarthritis
piroxicam
70
para-aminophenol derivative; no affinity for active site of COX (may have increased selectivity for brain COX); oral admin; metabolism by glucoronidation and sulfation, also CYP 2E1; renal excretion; tx: acute pain and fever, NO anti-inflammatory effects SE: hepatic toxicity
acetaminophen
71
irreversible inhibitor of COX 1&2
acetylsalicylic acid
72
oral absorption, crosses BBB and placenta, dose-dependent half-life, renal elimination, uricosuric
aspirin
73
selective COX-2 inhibitor; sulfonamide side chain; oral admin; CYP 2C9 metabolism; tx: RA/osteoarthritis, dysmenorrhea, acute pain, colorectal polyps SE? CI?
celecoxib SE: hypersensitivity, increase risk of GI irritation/bleeding/ulceration, MI, anemia CI: sulfonamide toxicity, NSAID hypersensitivity, CV risk factors, history of GI bleeding, 2C9 deficiency
74
pyrrole derivative; reversible inhibitor of COX 1&2; oral, IV & IM; alternative for opioid analgesics in treating post-op pain (\>inflammation) SE: serious adverse GI, renal fx, bleeding and hypersensitivity
ketorolac
75
reversible inhibition of COX 1&2, 3-4x/day tx: inflammatory diseases, rheumatoid disorders, fever, dysmenorrhea, osteoarthritis, IV form used to induce closure of PDA
ibuprofen
76
reversible inhibition of COX 1&2, oral & IV, 35-50% have adverse effects (give at night) tx: gout, close PDA, not pain/fever
indomethacin
77
oxicam derivative; reversible, non-selective; pro-drug; oral admin (1x/day); active metabolite may be more COX-2 specific; tx: manage osteoarthritis and RA
nabumetone
78
reversible inhibition of COX 1&2, once/day tx: ankylosing spondylitis, osteoarthritis, acute gout, rheumatoid disorders, fever, dysmenorrhea
naproxen
79
salicylate; effect independent of COX inhibition: inhibit cytokine production and lipoxygenase, free radical scavenger; tx: ulcerative colitis, RA; sulfa moiety = high % adverse effects
sulfasalazine
80
oxicam derivative; reversible, non-selective; oral admin (1x/day); long half-life, CYP 2C9 metabolism; tx: acute and chronic RA/osteoarthritis
piroxicam
81
para-aminophenol derivative; no affinity for active site of COX (may have increased selectivity for brain COX); oral admin; metabolism by glucoronidation and sulfation, also CYP 2E1; renal excretion; tx: acute pain and fever, NO anti-inflammatory effects SE: hepatic toxicity
acetaminophen
82
irreversible inhibitor of COX 1&2
acetylsalicylic acid
83
oral absorption, crosses BBB and placenta, dose-dependent half-life, renal elimination, uricosuric
aspirin
84
selective COX-2 inhibitor; sulfonamide side chain; oral admin; CYP 2C9 metabolism; tx: RA/osteoarthritis, dysmenorrhea, acute pain, colorectal polyps SE? CI?
celecoxib SE: hypersensitivity, increase risk of GI irritation/bleeding/ulceration, MI, anemia CI: sulfonamide toxicity, NSAID hypersensitivity, CV risk factors, history of GI bleeding, 2C9 deficiency
85
pyrrole derivative; reversible inhibitor of COX 1&2; oral, IV & IM; alternative for opioid analgesics in treating post-op pain (\>inflammation) SE: serious adverse GI, renal fx, bleeding and hypersensitivity
ketorolac
86
reversible inhibition of COX 1&2, 3-4x/day tx: inflammatory diseases, rheumatoid disorders, fever, dysmenorrhea, osteoarthritis, IV form used to induce closure of PDA
ibuprofen
87
reversible inhibition of COX 1&2, oral & IV, 35-50% have adverse effects (give at night) tx: gout, close PDA, not pain/fever
indomethacin
88
oxicam derivative; reversible, non-selective; pro-drug; oral admin (1x/day); active metabolite may be more COX-2 specific; tx: manage osteoarthritis and RA
nabumetone
89
reversible inhibition of COX 1&2, once/day tx: ankylosing spondylitis, osteoarthritis, acute gout, rheumatoid disorders, fever, dysmenorrhea
naproxen
90
salicylate; effect independent of COX inhibition: inhibit cytokine production and lipoxygenase, free radical scavenger; tx: ulcerative colitis, RA; sulfa moiety = high % adverse effects
sulfasalazine
91
oxicam derivative; reversible, non-selective; oral admin (1x/day); long half-life, CYP 2C9 metabolism; tx: acute and chronic RA/osteoarthritis
piroxicam
92
inhaled anti-inflammatory agent, tx: chronic control of asthma, prophylaxis; prevents mast cell degranulation, inhaled
cromolyn sodium (not a rescue medicine)
93
decreases amount of antigen-specific IgE that normally binds to and sensitizes mast cells; sub q; tx: allergic asthma SE: injection site reaction, anaphylaxis
omalizumab
94
first generation H1 receptor blockers
diphenhydramine, dimenhydrinate, chlorpheniramine, promethazine
95
second generation H1 receptor blockers
fexofenadine, loratidine, cetirizine, desloratidine
96
pharmacological effect of H1 antagonists
inhibit vascular permeability, suppress itching, no effect on BP, no effect on bronchoconstriction
97
CNS effects of H1 antagonists
sedation in 1st generation (except stimulation in children), anti-cholinergic effect (aids motion sickness)
98
peripheral and central anti-cholinergic effect of H1 antagonists
atropine-like, dry mucus membranes, urinary retention
99
major side effects of 1st generation Histamine blockers (+ 2 reasons)
sedation: 1) enter CNS and block H1 receptors 2) non-specific and block central cholinergic receptors in CNS
100
major side effect of "early" second generation drugs (Histamine blockers)
major cardiovascular toxicity when given with certain antibiotics (no longer in US) little to no anticholinergic effects because don't cross BBB
101
first generation H1 blocker; tx: allergies, motion sickness non-prescription sleep aid, Parkinson's SE: profound sedation
diphenhydramine (benadryl)
102
first generation H1 blocker, tx: allergies SE: some get drowsiness
chlorpheniramine
103
2nd generation H1 blocker
fexofenadine (allegra)
104
2nd generation H1 blocker + CYP metabolism
loratadine (claritin) (metabolized by 3A4 and 2D6 to desloratadine)
105
2nd generation H1 blocker
desloratadine (clarinex)
106
1st generation H1 blocker; tx: motion sickness, vestibular disturbances
dimenhydrinate (drammamine)
107
1st generation H1 blocker; tx: motion sickness, chemo-induced nausea/vomiting
promethazine
108
H2 receptor blocker; most adverse effects (why?)
cimetidine (inhibits P450 metabolism, prolongs half-life of other drugs)
109
H2 receptor blocker, medium potency; oral administration; tx: GERD
ranitidine
110
H2 receptor blocker, most potent; oral administration; tx: GERD
famotidine
111
2nd generation antihistamine, most sedation of 2nd generation drugs; oral administration; tx: GERD, formerly for Zollinger-Ellison syndrome
cetirizine (zyrtec)
112
H2 receptor antagonist tx
peptic ulcer disease, GERD, peptic ulcer from h. pylor, NSAID-induced gastric injury
113
pharmacological profile of H2 antagonists
reversible competitive inhibitiors (act as inverse agonists); inhibit basal gastric acid secretion, inhibit nocturnal gastric acid secretion, reduce volume of gastric acid and H+ concentration
114
SE of cimetidine
seen with long term use at high doses: decreased testosterone binding, inhibition of CYP that hydroxylates estradiol (gynecomastia, impotence)
115
Competitive, selective AT1 receptor antagonist Orally active Treatment of essential hypertension Decreases preload and after load
Losartan Contraindicated for volume depleted or on diuretics, pregnancy, cirrhosis
116
SE of losartan
dizziness, cough, angioedema
117
What are the ace inhibitors?
Captopril Enalapril Lisinopril
118
Mechanism of ACE inhibitors
Inhibit ACE, block Angiotension II formation and Bradykinin degradation Decreases preload and afterload Increase CO Contraindicated for: volume depleted or on diuretics (enhance their action)
119
Which of the ACT inhibitors are pro-drugs?
Enalapril Lisinopril
120
Side Effects of Captopril
Rash, Proteinuria, neutropenia
121
Renin inhibitor - blocks binding site for angiotensinogen, non peptide Long acting Anti-hypertensive enhanced by diuretic, ACE inhibitor or angiotensin antagonist
Aliskiren
122
Competitive Aldosterone antagonists, block mineral corticoid receptor
Spirinolactone, eplerenone Reduce mortality from heart failure Used with thiazide or loop diuretic to treat htn or edema
123
B andrenergic antagonists
Metoprolol and Propranolol
124
CCBs improve cardiac function by?
reducing afterload increasing oxygen supply (vessel dilation) normalizing heart rate in SVT (no affect on preload)
125
contraindications for diltiazem and verapamil
hypotension AV heart block sinus bradycardia CHF
126
contraindications for nifedipine and amlodipine
hypotension severe cardiac failure
127
adverse effects of diltizaem
hypotension, peripheral edema, CHF (worsens), AV block
128
adverse effects of verapamil
hypotension, headaches, peripheral edema, constipation, CHF (worsen), AV block
129
adverse effects of dihyropyridines
hypotension (!), headaches (!), peripheral edema (!)
130
Phenylalkylamine
Verapamil
131
Benzothiazepine
Diltiazem
132
1,4-Dihydropyridines
Nifedipine (prototype) Amlodipine (longest acting)
133
Use-dependent CCBs
Verapamil Diltiazem
134
Voltage-dependent CCBs
Nifedipine Amlodipine
135
What CCB do you use for Angina?
Diltiazem Because decreases SA node firing rate, reduces cardiac after load by vasodilation, also increases blood flow to myocardium to prevent ischemia Nifednipine and Amlodipine can also be used because they reduce myocardial oxygen demand and arterial pressure
136
What CCBs are used for Supraventricular arrhythmias?
Diltiazem or Verapamil Because they reduce the firing rate of the SA node and reduce conduction through AV node
137
Which CCBs are used to treat hypertension?
Usually Dihydropyridines Because of potent vasodilator effects BUT may trigger reflex tachycardia particularly with short acting Dihydropyridines
138
Diuretics, Vasodilators
Fenoldopam, Dopamine, Atriopeptins
139
What is the mechanism of action of the vasodilatory diuretics??
Increase RBF without decreasing GFR FF decreases (reduces protein conc and hydroosmotic forces in peritubular capillaries)-- allow Na and H20 to leak back into the tubule This reduces net reabsorption so Na excretion increases Weak as diuretics due to compensatory Na reabsorption in more distal nephron segment
140
Osmotic diuretic Freely filterable at glomerulus Not reabsorbed Metabolically inert
Mannitol
141
What is the mechanism of action of osmotic diuretics??
Given intravenously Act in tubular lumen as non-reabsorbable solute Urine volume and sodium excretion are proportional to the osmotic load Increases the urinary excretion of sodium, potassium, chloride, water and mannitol
142
What are osmotic diuretics used for?
Edema Glaucoma-reduces intraocular pressure Acute renal failure
143
Carbonic Anhydrase Inhibitor Orally active Weak diuretics Inhibited by acidosis-limits clinical use
Acetazolamide
144
What is the mechanism of carbonic anhydrase inhibitors?
Filtered and secreted by the organic acid transporter (OAT) - acts from tubular lumen Inhibit carbonic anhydrase in the proximal and distal tubule Carbonic anhydrase provides hydrogen ions for bicarbonate reabsorption Increase the excretion of sodium, potassium, bicarbonate and water Alkalinize the urine
145
What are Carbonic Anhydrase inhibitors used for?
Glaucoma - reduced aqueous humor formation and intraocular pressure Alkalinize the urine -- decrease drug toxicity Mountain or altitude sickness Anticonvulsant SE= Metabolic acidosis, hypokalemia
146
Loop Diuretics Rapid onset, short duration of action
Furosemide, Bumetanide, Ethacrynic Acid
147
What is the mechanism of Loop Diuretics??
Filtered and secreted by the OAT Inhibits Na-K-2Cl symporter Acts on cortical and medullary segments of the ascending limb of the loop of Henle Increase excretion of Na, K, Cl and H20
148
What are the Loop Diuretics used for?
Edema of cardiac, hepatic or renal origin Acute pulmonary edema HTN
149
Thiazide and Thiazide-Like Diuretics Moderate onset of activity Long duration of action
Hydrochlorothiazide Metolazone
150
What is the mechanism of action of Thiazide diuretics?
Filtered and secreted by the OAT Inhibits Na-Cl symporter Acts on cortical segment of distal tubule Increases excretion of Na, K, Cl and H20 Urine is hypertonic - unable to dilute
151
What are the Thiazide Diuretics used for?
Edema due to CHF HTN Hypercalemia/Ca salt-renal caliculi
152
K+ Sparring Diuretics, Aldosterone Antagonists
Spironolactone, Eplerenone
153
K+ Sparring Diuretics, Na+ channel inhibitors
Amiloride, Triamterene
154
What is the mechanism of action of the Potassium Sparring Diuretics?
Increase sodium excretion, reduce potassium excretion, Increase the urinary excretion of Na, Cl and H20
155
What are the Potassium Sparring Diuretics used for?
Edema HTN Usually used in combo with thiazide loop diuretic to enhance natriuresis without potassium loss
156
Inhibits coagulation proteases (II, Xa, IXa) by antithrombin III activation (1000x)
Heparin
157
LMWH - binds and accelerates antithrombin III activation
Enoxaparin
Dalteparin
158
Direct Thrombin inhibitor, IV
Lepirudin
Bivalirudin
159
Specific reversible direct thrombin inhibitor
Inhibits thrombin-mediated effects -- fibrinogen, V, VIII, XI, XIII cleavage, platelet aggregation
Dabigatran
160
Reversible Xa binding
Rivaroxaban
161
Xa Inhibitor
Fondaparinux
162
Heparin antagonist
Protamine sulfate
163
Inhibits VKORC
Competitive inhibitor of vitamin K --\> inactivation of II, VII, IX, X
Warfarin
164
Binds fibrin
Activates fibrin-bound plasminogen --\> plasmin = clot resolultion
Tissue plasminogen activate (t-PA)
Alteplase
165
Binds plasminogen --\> activate site exposed, activates another plasminogen
Streptokinase
166
Procoagulant - potent inhibitor of fibrinolysis
Competes with fibrin for plasmin
Aminocaproic Acid
167
Irreversible COX inhibitor (acetylation)
Uricosuric agent
Aspirin
168
Phosphodiesterase inhibition,
Increase cAMP, decrease platelet aggregation
Dipyridamole
169
Prodrugs
Bind P2Ya/P2Y12 receptors to inhibit Gi activation
Increase cAMP
Ticlopidine
Clopidogrel
Prasugrel
Ticagrelor
170
Glycoprotein IIb/IIIa receptor blocker
Blocks fibrinogen binding and platelet cross-linking
Abciximab
171
Glycoprotein IIb/IIIa receptor blocker
Blocks fibrinogen binding and platelet crosslinking
Eptifibatide
