Drugs

Question 1

When is propranolol indicated?

Answer 1

thyroid storm; beta-blockers shut down the widespread sympathetic activity –>IV

Question 2

When are calcium channel blockers indicated?

Answer 2

ditiazem; used for thyroid storm is patient is not able to tolerate beta-blockers

Question 3

propylthiouracil (PTU) and methimazole are indicated for what thyroid disorder?

Answer 3

hyperthyroidism

Question 4

what is the black box warning for PTU?

Answer 4

liver failure/severe liver injury

Question 5

MOA PTU

Answer 5

inhibits oxidation of iodine

Question 6

How many doses a day for PTU?

Answer 6

multiple, unlike methimazole

Question 7

Which is preferred for a younger population: methimazole or PTU

Answer 7

methimazole

Question 8

Which one can be used in thyroid storm: PTU or methimazole?

Answer 8

PTU

Question 9

Most common AE of methimazole

Answer 9

hypothyroid

Question 10

synthetic T4

Answer 10

levothyroxine

Question 11

synthetic T3

Answer 11

liotrix

Question 12

AE of liotrix

Answer 12

cardiovascular risks! increased BP, anxiety, tremor, increased appetite

Question 13

what are the rapid onset insulins?

Answer 13

lispro, aspart, gluisine

Question 14

What is the longest acting insulin

Answer 14

glargine (24 hr duration)

Question 15

What is an intermediate long acting insulin?

Answer 15

detemir (17 hr duration)

Question 16

What’s the onset of regular insulin?

Answer 16

30-60 minutes

Question 17

What’s the difference between insulin bolus and basal?

Answer 17

bolus: rapid analogs for meals
basal: long acting analogs

Question 18

How do you initiate insulin treatment is DM II?

Answer 18

start by keeping oral doses at adding bedtime dose or long acting analog

Question 19

When is glucocorticoid use indicated?

Answer 19

Addison’s, adrenal (cortisol) insufficiency

Question 20

What should you give with glucocorticoid steroids?

Answer 20

PPI’s- to protect the GI tract

Question 21

What is fludrocortisone?

Answer 21

mineralocorticoid; MUST TAPER

Question 22

alendronate, risendronate, pamidronate, zoledronic acid are in what drug class?

Answer 22

bisphosphonates

Question 23

What are bisphosphonates used for?

Answer 23

osteoporosis, paget’s disease

Question 24

What is raloxifene?

Answer 24

selective estrogen receptor modulator;

Question 25

what is raloxifene used for?

Answer 25

prevents bone loss post-menopause but decreases effectiveness of levothyroxine

Question 26

what are you at increased risk for when using estrogen therapy?

Answer 26

increased risk of breast cancer and endometrial cancer; don’t use with grapefruit juice

Question 27

Indications for calcitonin

Answer 27

reduces bone resorption, also relieves pain