Drugs 2 Flashcards
Which drugs cause a dry mouth?
levodopa
tricyclic antidepressants
isotretinoin
antipsychotics
Which drugs can cause heart failure?
diltiazem
verapamil
What monitoring is required for cardiovascular drugs?
Statins: LFT (baseline, 3 and 12 months)
ACE inhibitors: U+Es (prior to treatment, after increasing dose, at least annually)
Amiodarone: TFT, LFT (TFT, LFT, U&E, CXR prior to treatment, TFT, LFT every 6 months
What is the monitoring for rheumatology drugs?
Methotrexate: FBC, LFT, U+E (before starting treatment and repeated weekly until therapy stabilised, thereafter patients should be monitored every 2-3 months)
Azathioprine: FBC, LFT (FBC, LFT before treatment
FBC weekly for the first 4 weeks
FBC, LFT every 3 months)
What is the monitoring for neuropsychiatric drugs?
Lithium: Lithium level, TFT, U&E (TFT, U&E prior to treatment, Lithium levels weekly until stabilised then every 3 months, TFT, U&E every 6 months)
Sodium valproate: LFT (LFT, FBC before treatment
LFT ‘periodically’ during first 6 months)
Which drugs cause precipitation of digoxin toxicity?
amiodarone diltiazem verapamil loop diuretics thiazides ciclosporin quinidine
What are the side effects of quinolones? (ciprofloxacin and levofloxacin)?
lower seizure threshold in patients with epilepsy tendon damage (including rupture) - the risk is increased in patients also taking steroids cartilage damage has been demonstrated in animal models and for this reason quinolones are generally avoided (but not necessarily contraindicated) in children lengthens QT interval Avoid in women who are pregnant or breastfeeding
Which drugs cause peripheral neuropathy?
amiodarone isoniazid vincristine nitrofurantoin metronidazole
Which drugs cause fluid retention?
corticosteroids
pioglitazone
ciclosporin
Which drugs cause hyperlipidaemia?
corticosteroids
isotretinoin
