Drugs Flashcards
1
Q
Triptan:
A
Sumatriptan
2
Q
Ditans:
A
Lasmiditan
3
Q
Gepant:
A
Rimegepant
Ubrogepant
4
Q
Monoclonal antibodies:
A
Erenumab
Eptinezumab
Fremanezumab
5
Q
Sumatriptan moa:
A
5HT1b/1d receptor agonist
Constricts the cranial blood vessels
(targeting the trigeminal ganglia outside the BBB)
Inhibiting the release of pro-inflammatory peptides (Reduces the levels of CGRP)
6
Q
Sumatriptan Side effects and contraindications
A
Triptans are contraindicated in cardiovascular disease (they can cause coronary vasospasm)
Side effects: Nausea, vomiting, Hot flushes, Drowsiness
7
Q
Lasmiditan moa
A
5HT1f agonist.
Inhibits trigeminal neuronal activity
Inhibiting the firing of trigeminal nerves
(5HT1f receptors are found in nerve terminals of C-fibres)
