Antiviral therapy

Question 1

How/when is it realistic to use sotrovimab to prevent virus entry?

Question 2

What is Sotrovimab?

Answer 2

A human monoclonal antibody.
It binds to the spike protein receptor binding domain of SARS-COV-2 and neutralises it.
Intravenous route of administration

Licensed for mild to moderate COV-19 infection in high risk patients

Question 3

What is Mab114?
MOA

Answer 3

A human monoclonal antibody. Binds to the glycoprotein on Ebola virus to block its entry into host cells. This leads to antibody-dependent cell cytotoxicity.

Question 4

Why do viruses need cells

Question 5

List the virus lifecycle steps

Answer 5

1-Entry
2-Replication
3-Egress

Question 6

Identify the 3 steps of the SARS-COV-2 life cycle

Question 7

Describe the first step of the SARS-COV-2 life cycle

Question 8

How can sotrovimab be used to treat COVID-19

Answer 8

sotrovimab binds to the spike protein (receptor binding domain) of SARS-COV-2 and neutralises it

Question 9

Describe the second step of the viral life cycle

Question 10

Describe the second step of the viral life cycle.
How does Remdesivir inhibit this?

Question 11

How can Remdesivir work against two different viruses? (COVID and Ebola)

Question 12

What are the three steps in the viral life cycle/ SARS-COV-2?

Answer 12

Entry
Replication
Egress

Question 13

What is Viral egress?

Answer 13

Viral egress is the process of viral escape from the cell that is frequently coupled with viral biogenesis. For enveloped viruses, this process must involve the acquisition of a lipid envelope.

Question 14

What are the advantages of using REGN-EB3 over MAb114?

Answer 14

REGN-EB3 targets several different epitopes = reduces the selection of resistant virus