Drugs

Question 1

Bisphosphonates:

IV version

Tablets

Answer 1

Zolendrolic acid

Alendronic acid

Question 2

Fungal and bacterial infection tx when someone on warfarin

Answer 2

Can’t use fluconazole or metronidazole so use nystatin

Question 3

Action of 3 different types of anti fungal drugs

Answer 3

Azoles inhibit ergosterol synthesis

Polyenes bind to ergosterol to make permiable cell wall = death

Echinocandins (caspofingin)

Question 4

What antibiotic is used for prophylaxis now and why? (I.e. for IE)

Answer 4

Amoxicillin 3g 60 mins before

Question 5

What antibiotic used for abscesses

Answer 5

Pen v 500mg 4X daily for 5 days

If allergic to penicillins
= metronidazole 3x5 400mg

Question 6

Aspirin, ibuprofen, paracetamol direct effects on a specific cycle

Answer 6

Lipoxygenease cycle

These analgesics work by inhibiting COX1 or COX2 which in turn inhibits prostaglandin production and in turn reduce tissue sensitivity to pain

Paracetamol effects COX2 more and less COX1 (COX1 important for maintaining lining of stomach) this makes this okay for GIT patients