Drugs

Question 1

THC

Answer 1

Partial agonist at C1

Question 2

Terpenoids

Answer 2

anti-inflammatory, anti-bacterial, and anti-anxiety effects
Gives smell
Non-cannabinoid

Question 3

Cannabidiol (CBD)

Answer 3

Negative allosteric modulator at CB1

Question 4

Nabilone

Answer 4

Synthetic Cannabinoid

Partial agonist at C1

Synthetic analog

Question 5

Dronabinol

Answer 5

Synthetic Cannabinoid

Partial agonist at C1

Transisomer

Question 6

Nabiximols

Answer 6

Cannabis extract

Question 7

Rimonabant

Answer 7

Synthetic Cannabinoid

Inverse agonist

Question 8

Anandamide (AEA) and 2-arachinoyl glycerol (2-AG)

Answer 8

Endocannabinoids

Retrograde neurotransmitters made on demand

Function as a break

Question 9

Buprenorphine

Answer 9

Mu partial agonist
Kappa + Delta Antagonist

Replacement agonist

Question 10

Methadone

Answer 10

Mu full agonist

Replacement agonist

Question 11

UGTB7

Answer 11

Morphine metabolism enzyme

Question 12

Cytochrome C P450 2C9

Answer 12

Forms THC metabolites

Question 13

11-OH-THC
THC-COOH

Answer 13

Active
Inactive

THC metabolites

Question 14

CYP2D6

Answer 14

Codeine to morphine enzyme

Question 15

TRV 250

Answer 15

Delta Opioid Agonist

Biased for GPCR, promoting analgesic effects

Question 16

Salvia

Answer 16

Kappa agonist can cross the brain

Hallucinations

Question 17

CR845

Answer 17

Kappa agoinst can not cross brain

Inhbits pain by binding to kappa receptors on the skin

Question 18

Benzodiazepines

Answer 18

Anti-seizure

Positive Allosteric Modulators at GABA

Increase frequency (potency)

Question 19

Barbiturates

Answer 19

Positive Allosteric Modulators at GABA

Increase duration (efficacy )

Question 20

Vigabatrin

Answer 20

Inhibits GABA-T (GABA-T degrades GABA)

Question 21

Tigabine

Answer 21

Antiseizure

Inhibits GABA transporter (GAT-1)

Question 22

Carbamazepine

Answer 22

Anti-seizure

Causes conformation change in voltage gated sodium channels that blocks the channel

Question 23

Gabapentin

Answer 23

Looks like GABA, does not effect GABA receptors

Inhibits calcium gated ion channels

Question 24

Perampanel

Answer 24

Anti-seizure

Non competitive antagonist at AMPA receptor

Blocks excitation

Question 25

Ketanserin

Answer 25

Blocks LSD hallucinogenic effects

Question 26

LSD

Answer 26

Classical hallucinogenic

Partial agonist at 5HT-2a

Question 27

Psilocybin

Answer 27

Classical hallucinogenic
Prodrug
Partial agonist at 5HT-2a
Greater affinity at 5HT-2b/c

Question 28

Psilocin

Answer 28

Converted from psilocybin by liver

Question 29

Phencyclidine

Answer 29

Dissociative

NMDA receptor antagonist

Increases dopamine by inhibiting dopamine transporter
Addictive

Question 30

Scopolamine

Answer 30

Deliriant

Found in Datura stramonium

Competitive antagonist at muscarinic cholinergic receptors

Question 31

Atropine

Answer 31

Deliriant

Found in Datura stramonium

Competitive antagonist at muscarinic cholinergic receptors

Question 32

Salvinorin A

Answer 32

Active ingridient in Salvia

Agonist at the kappa opioid receptor

Question 33

CGRP

Answer 33

Released during pain stimulation in head

Causes vasodilation = migraines

Question 34

Sumatriptan

Answer 34

Migraine

Selective for 5-HT 1b/d agonist

Vasoconstriction and inhibition of trigeminal nerve

Avoids the side effects of ergotamine

Question 35

Rimegepant

Answer 35

CGRP receptor antagonists

Question 36

CGRP Antibodies

Answer 36

Monoclonal antibodies that bind to either CGRP receptors or to CGRP

Inhibits CGRP signalling leading to vasoconstriction

Question 37

Ipronazid

Answer 37

Antidepressant

Inhibits MAO

Question 38

Tyramine

Answer 38

Cheese

Degraded by MAO

Question 39

Fluoxetine

Answer 39

Inhibits serotonin transporters