Drugs Flashcards
1
Q
Glucocorticoid MOA
A
Upregulates a protein that binds to and inhibits NFKB –> Inhibits T-cell proliferation
2
Q
Azithioprine MOA
A
Interferes with DNA synthesis by alkylating DNA precursors
3
Q
MMF MOA
A
Interferes with denovo protein synthesis
4
Q
Calcineurin inhibitors
A
Cyclosporine A, Tacrolimus
5
Q
Cyclosporine A and Tacrolimus MOA
A
Calcineurin inhibitors- Blocks calcineurin dependent activation of NFAT, ultimately blocking T-cell activation and IL-2 production
6
Q
MTOR inhibitors
A
Sirolimus and Everolimus
7
Q
Sirolimus and Everolimus MA
A
Adhere to FKBP to inhibitor MTOR, resulting in cell cycle arrest by inhibiting IL-2
Blocks B and T -cell proliferation, preventing cell proliferation
8
Q
Belatacept
A
Adheres to CD80 and CD86, blocking APC and T-cell interaction
