Drugs

Question 0

Camptothecin

Answer 0

Stops Topo I, cancer treatment

Question 1

Azidothymidine (AZT)

Answer 1

Treats HIV, blocks reverse transcriptase, no 3’ OH

Question 2

Rifampin

Answer 2

Prokaryotic RNA Polimerase, inhibits initation of transcription, treats TB

Question 3

Etoposide

Answer 3

Topo II, cancer

Question 4

Streptomycin

Answer 4

An aminoglycoside

Prok, binds 30s ribosome, prevents assembly of translation proteins.

Question 5

Genatamacin

Answer 5

An aminoglycoside

Binds ribosome 30s, prevents initiation

Question 6

Tetracyclines

Answer 6

Minocycline, doxycycline, doxorubicin.

Binds 30s and blocks translation elongation by blocking the A site.

Question 7

Cuprofloxacin and Nalidixic

Answer 7

Quinolone drugs

Blocks prok DNA gyrase

Question 8

Acetazolamide

Answer 8

Carbonic anhydride inhibitor.

Inhibits water reabsorption in the kidney

Question 9

Sodium Butyrate

Answer 9

Histone Deacetylase (acetylation)

Increases euk transcription

Question 10

Chloramphenicol

Answer 10

Prokaryote pepsidal transferase, Inhibits peptide chain from moving from P site to A site

Question 11

Puromycin

Answer 11

Analog to aminoacyl-tRNA makes AA chain fall off

Question 12

Didanosine (ddl)

Answer 12

Viral reverse transcriptase
Nucleoside analog of adenosine
Lacks a 3’OH preventing elongation

Question 13

Vidarabine

Answer 13

Adenosine arabinoside (araA)
Reverse transcriptase inhibitor in treating Leukemia

2’OH creates steric hindrance preventing elongation.

Question 14

Decitabine

Answer 14

DNA Anti methylation (prevents turn off of tumor suppressor genes)

In RNA: 5-Azacytidine

Cytidine nucleoside analog

Question 15

Cytarabine: cytosine arabinoside (araC)

Answer 15

2’OH creates steric hindrance preventing elongation in DNA Pol

Cancer, leukemia

Question 16

Acyclovir

Answer 16

Viral reverse transcriptase lacking 3’OH

Herpes simplex Viral kinase adds 1st phos.

Question 17

Zidovudine

Answer 17

AZT
Viral reverse transcriptase
Lacks 3’OH

Treats HIV

Question 18

Tenofovir

Answer 18

Viral reverse transcriptase (HIV)
Open ring structure
Lacks 3’OH

Question 19

Actinomycin D

Answer 19

Intercalates guanine and cytosine preventing double strand separation in prok and euk

Anti cancer

Question 20

Colchicine

Answer 20

Euk microtubule assembly
Prevents alpha beta tubulin polymerization required for microtubule assembly

Cancer

Question 21

Alpha amanitin

Answer 21

Death cap mushrooms
Prevents transcription in euk RNA Poly II

Patients die of liver failure

Question 22

Cycloheximide

Answer 22

Blocks Euk peptidyl transferase, blocks growing peptide from P to A site

Question 23

Taxol

Answer 23

Stabilizes and prevents microtubule disassembly

Cancer

Question 24

Erythromycin

Answer 24

Binds 50s ribosome unit. Prevents translocation (ratcheting)

Question 25

Clindamycin

Answer 25

Stops ribosome from the translocating down mRNA. 50s subunit.

Question 26

Prozac (fluoxetine)

Answer 26

Inhibits Euk serotonin reuptake.

Enhances action of serotonin.

Question 27

Lysergic acid diethylamide (LSD)

Answer 27

Serotonin receptors in brain stem.

Question 28

Di-isopropyl fluorophosphate (DFP)

Answer 28

Irreversibly inhibits acetylcholinesterase. Binds to Ser.

Continuous stimulation of muscle contraction and overstimulation of the autonomic nervous system resulting in death.

Question 30

Allopurinol

Answer 30

suicide inhibitor of Xanthine Oxidase (forms uric acid)

Question 31

Bongkrekic Acid

Answer 31

binds inward portion of ATP/ADP transporter

Question 32

Atractyloside

Answer 32

binds outward portion of ATP/ADP transporter