Drugs

Question 1

which drugs work to affect synthesis

Answer 1

l tryptophan, l dopa

Question 2

which drugs work to affect storage

Answer 2

reserpine depletes NA and DA

Question 3

which drugs work to affect release from storage

Answer 3

amphetamine

Question 4

which drugs work to affect reuptake

Answer 4

SSRI, TCA, Cocaine, buprprion (NA DA)

Question 5

which drugs work to affectdegradation

Answer 5

MAO-I, Actelychol inhibs

Question 6

which drugs work to affect presynatpic

Answer 6

clonidine lofexidine Alpha-2

Question 7

which drugs work to affect post synatpic

Answer 7

most antipsychotics at D2

Question 8

which drugs work to affect partial agonism

Answer 8

aripiprazole, buspirone buprenoprhine

Question 9

full agonists

Answer 9

benzos, bromocrytidine

Question 10

ionotropic receptors

Answer 10

nicotinic, GABA-a, glutamate, serotonin 5HT3

Question 11

metabotropic

Answer 11

dopamine, noradrenaline, serotonin, muscarinic, opiod

Question 12

competitive antagonists

Answer 12

atropine, propanolol

Question 13

amisulpride

Answer 13

D2/3 antagonism, limbic selective, 5HT7 activity

Question 14

aripiprazole

Answer 14

D2 partial agonist, 5HT2A antagonist

Question 15

asenapine

Answer 15

D2 antagonist, 5HT2A antagonist, potent A-2 blockade

Question 16

chlorpromazine

Answer 16

antimuscarinic, D2 blockade

Question 17

clozapine

Answer 17

high 5ht2a to d2 ratio also D4 and 5ht6, A1- antagonist

anticholinergic and antihistaminergic. 5ht3. hit and run

Question 18

lurasidone

Answer 18

similar to risperidone, minimal alpha 1 and histamine - weight neutral

Question 19

olazapine

Answer 19

high 5ht2/d2 ratio, potent d4 blockade, antihistamierigc, anticholinergic

Question 20

quetiapine

Answer 20

like clozapine, less 5ht2 profile

Question 21

risperidone

Answer 21

high 5ht2 profile, in higher doses can bind strongly to d2, can cause prolactin and epses

Question 22

sulpride

Answer 22

pure d 2 antagonist

Question 23

agomelatine

Answer 23

5ht2c antagonism, MT1/2 agonist,

Question 24

buproprion

Answer 24

DA and NA reuptake inhibitor, competitive nocotinic antagonism

Question 25

citalopram

Answer 25

SSRI - most selective

Question 26

clomipramine

Answer 26

most potent TCA, more selective

Question 27

desipramine

Answer 27

least anticholinergic but lethal in overdose

Question 28

lithium

Answer 28

increase tryptophan uptake into cells
enhacne serotonin release
downregulate 5ht1a
inhibit gsk 3
inositol second messenger systems

Question 29

mirtazepine

Answer 29

5ht2a antagonist, alpha 2 antagonist, antihistmainergic, andti 5ht3,

Question 30

mianserin

Answer 30

similar to mirtazepine, but more anitcholinergic than histamine

Question 31

moclobemide

Answer 31

RIMA

Question 32

paroxetine

Answer 32

most signifcant side effects, antimuscarinic

Question 33

trazodone

Answer 33

5ht2a/2c blocker, alpha 2 blocker, alpha 1 blocker

Question 34

vortioxetine

Answer 34

similra to reboxetine, mainylssri effect though, 5ht3 block, 5ht1a agonist

Question 35

carbemazepine

Answer 35

prolongs sodium channel activiation

reduce glutamate

Question 36

gabapentin

Answer 36

like gaba. binds to voltage dependant calcium channel.
increases gaba availabilty
high affinity for gaba - a but not like a benzo

Question 37

lamotrigine

Answer 37

blocks volatge gated sodium channels,

Question 38

levetiractetam

Answer 38

enhance gaba system

Question 39

pregabalin

Answer 39

like gaba, binds to votage gated calciu channel,

Question 40

vigabatrin

Answer 40

gaba transaminas inhibtor

Question 41

benzos

Answer 41

omega site gaba a complex

all agonist apart from clonzepam - partial

Question 42

Z drugs

Answer 42

omega 1

Question 43

effects of ect

Answer 43

bbb permeablity briefly
increase bdnf
most hormone go up
most receptors go down
DA and 5ht goes up in hippocampus and amygdala
reduce beta receptors,