Drugs Flashcards
1
Q
Nitrous Oxide MAC
A
104
2
Q
Nitrous Oxide Blood:Gas
A
0.47
3
Q
Desflurane MAC
A
6
4
Q
Desflurane MAC 60-70% N20
A
2.8
5
Q
Desflurane Blood:Gas
A
0.42
6
Q
Sevoflurane MAC
A
2.1
7
Q
Sevoflurane MAC in 60-70% N20
A
0.66
8
Q
Sevoflurane Blood:Gas
A
0.63-0.69
9
Q
Isoflurane MAC
A
1.15
10
Q
Isoflurane MAC in 60-70% N20
A
0.5
11
Q
Isoflurane Blood:Gas
A
1.43
12
Q
Lidocaine Onset
local anesthetic section
A
Rapid-Mod
13
Q
Bupivicaine Onset
A
Moderate
14
Q
Ropivicaine Onset
A
Moderate
15
Q
Exparel (bupivicaine liposome injectable suspension) Onset
A
Moderate
16
Q
Exparel Duration Spinal
bupivicaine liposome injectable suspension
A
96 hrs after local infiltration and 120 hours after interscalene brachial plexus nerve block
17
Q
Exparel (bupivicaine liposome injectable suspension) MAX DOSE
A
266 Mg (20 ml)
18
Q
Exparel (bupivicaine liposome injectable suspension) pKa
A
8.1
19
Q
Exparel (bupivicaine liposome injectable suspension) Elimination
A
Hep
20
Q
Exparel (bupivicaine liposome injectable suspension) Mechanism of Action
A
Amide NA+ channel Blocker
21
Q
Ropivicaine Duration Spinal
A
2-3.5 hours
22
Q
Ropivicaine Duration Epidural
A
120-180 mins
23
Q
Ropivicaine MAX DOSE mg/kg
A
200mg plain/ 250 MG/epi
24
Q
Ropivicaine Max dose plain mg/kg
A
3mg/kg
25
Ropivicaine Max Dose with Epi mg/kg
3 mg/kg
26
Ropivicaine pKa
8.1
27
Ropivicaine Elimination
Hep
28
Ropivicaine Mechanism
Amide Na+ BHannel Blocker
29
Bupivicaine Duration Spinal
2-3 hours
30
Bupivicaine Duration Epidural
120-200 mins
31
Bupivicaine Max Dose
175mg plain 225 mg/epi
32
Bupivicaine Max Dose Plain mg/kg
2.5 mg/kg
33
Bupivicaine pKa
8.1
34
Bupivicaine Elimination
Hep
35
Bupivicaine Mechanism of Action
Amide Na+ Channel Blocker
36
Lidocaine Duration Spinal
60-70 mins
37
Lidocaine Max Dose
350 mg plain, 500mg/epi
38
Lidocaine Max Dose Plain mg/kg
4.5 mg/kg
39
Lidocaine pKa
7.9
40
Lidocaine Elimination
Hep
41
Lidocaine Mechanism of Action
Amide Na+ Channel Blocker
42
Ondansetron vial
2mg/ml
43
Ondansetron Dose
4 mg
44
Ondansetron Conc
-
45
Ondansetron Onset
<30 min
46
Ondansetron Peak
2 hrs
47
Ondansetron Duration
12 hours
48
Ondansetron T1/2 Beta
3.5 hours
49
Ondansetron Elimination
Hep
50
Ondansetron MOA
5HT antagonist
51
Decadron vial
4 mg/ml
52
Decadron Dose
4mg/ml
53
Decadron Conc
-
54
Decadron Onset
5 mins / 4-8 hours
55
Decadron Peak
6-12 hours
56
Decadron Duration
24-72 hours
57
Decadron T1/2B
3.5 - 4.5 hours
58
Decadron Elimination
Hep
59
Decadron MoA
Glucocorticoid
60
Acetaminophen (Ofirmev) vial
1000mg /100ml
61
Acetaminophen (Ofirmev) Dose
1000 mg over 15 mins
62
Acetaminophen (Ofirmev) conc
10mg/ml
63
Acetaminophen (Ofirmev) Onset
15 mins
64
Acetaminophen (Ofirmev) Peak
1 hour
65
Acetaminophen (Ofirmev) Duration
4-6 hours
66
Acetaminophen (Ofirmev) T1/2B
2.4 hours
67
Acetaminophen (Ofirmev) Elimination
Hep
68
Acetaminophen (Ofirmev) MoA
Central inhibition of prostiglandin synthesis
69
Vasopressin Vial
20 units/ml
70
Vasopressin Dose
0.2 units
71
Vasopressin Conc
0.2 units/ml
72
Vasopressin Onset
< 1 min
73
Vasopressin Peak
15 mins
74
Vasopressin Duration
20 mins
75
Vasopressin T1/2B
10-20 min
76
Vasopressin Elimination
Hep
77
Vasopressin Mix
20 units in 100 ml
78
Vasopressin MoA
Vasopressin Receptors
79
Esmolol vial
10 mg/ml
80
Esmolol dose
1ml TTE/10 mg
81
Esmolol Conc
10mg/ml
82
Esmolol Onset
2 min
83
Esmolol Peak
10 min
84
Esmolol Duration
10-30 min
85
Esmolol T1/2B
8-9 min
86
Esmolol Elimination
nonspecific blood & Tissue Esterases
87
Esmolol Mix
n/a
88
Esmolol MoA
Beta 1 Antagonist
89
Labetalol Vial
5mg/ml
90
Labetalol dose
1 ml TTE/ 5 mg
91
Labetalol Conc
5 mg/ml
92
Labetalol Onset
2-5 mins
93
Labetalol Peak
5-15 mins
94
Labetalol Duration
2-4 hours
95
Labetalol T1/2B
5 hours
96
Labetalol Elimination
Hep/Renal
97
Labetalol Mix
n/a
98
Labetalol MoA
Beta 1&2 and Alpha Antagonist (7:1)
99
Glycopyrrolate vial
0.2 mg/ml
100
Glycopyrrolate dose
0.1 - 0.2 mg
101
Glycopyrrolate Conc
0.2 mg/ml
102
Glycopyrrolate Onset
1 min
103
Glycopyrrolate Peak
5 min
104
Glycopyrrolate Duration
2-3 hours
105
Glycopyrrolate T1/2B
80 mins
106
Glycopyrrolate Elimination
Help/Renal
107
Glycopyrrolate Mix
0.2mg/ml
108
Glycopyrrolate MoA
Antimuscarinic
109
Atropine Vial
0.4 mg/ml or 1 mg/ml
110
Atropine Dose
0.5 - 1 mg
111
Atropine Conc
1 mg/ 2.5 ml
112
Atropine Onset
1 min
113
Atropine Peak
2-4 min
114
Atropine Duration
30-60 min
115
Atropine T1/2B
4 hours
116
Atropine Elimination
Hep
117
Atropine Mix
0.4 mg/ml
118
Atropine MoA
Antimuscarinic
119
Epinephrine vial
1 mg/ml
120
Epinephrine dose
1 ml TTE/ 10 mcg
121
Epinephrine Conc
10 mcg/ml
122
Epinephrine Onset
30-60 sec
123
Epinephrine Peak
< 3 min
124
Epinephrine Duration
5-10 min
125
Epinephrine T1/2B
2-4 min
126
Epinephrine Elimination
MAO/Hep
127
Epinephrine Mix
0.1 ml of 1:1000 in 10 ml NS
128
Epinephrine MoA
Direct Alpha & Beta Agonist
129
Ephedrine vial
50mg/ml
130
Ephedrine Dose
1 ML TTE/ 5 mg
131
Ephedrine Conc
5 mg/ml
132
Ephedrine Onset
< 1 min
133
Ephedrine Peak
2-5 min
134
Ephedrine Duration
10 min
135
Ephedrine T1/2B
3 hours
136
Ephedrine Elimination
Hep/Renal
137
Ephedrine Mix
50 mg in 9 ML
138
Ephedrine MoA
Direct and Indirect Alpha & Beta Agonist
139
Phenylephrine vial
10mg/ml
140
Phenylephrine Dose
1ml TTE/40 mcg
141
Phenylephrine Conc
40 mcg/ml
142
Phenylephrine Onset
< 1 min
143
Phenylephrine Peak
1 min
144
Phenylephrine Duration
5-10 min
145
Phenylephrine T1/2B
2 hours
146
Phenylephrine Elimination
Hep
147
Phenylephrine Mix
10 mg in 249 ml
148
Phenylephrine MoA
Alpha 1 agonist
149
Sugammadex vial
100mg/ml
150
Sugammadex Dose
2 mg/kg (2 twitches), 4 mg/kg (no twitches), 16mg/kg (3 mins after induction)
151
Sugammadex Onset
Fast
152
Sugammadex Peak
Fast
153
Sugammadex Duration
Depends on dose
154
Sugammadex T1/2B
120 min
155
Sugammadex Elimination
Renal
156
Sugammadex MoA
y-cyclodextrin complexes with Rocuronium and Vecuronium
157
Glycopyrrolate (reversal adjunct) vial
0.2mg/ml
158
Glycopyrrolate (reversal adjunct) Dose
0.2 mg per mg of neostigmine
159
Glycopyrrolate (reversal adjunct) Onset
1 min
160
Glycopyrrolate (reversal adjunct) Peak
5 min
161
Glycopyrrolate (reversal adjunct) Duration
2-3 hours
162
Glycopyrrolate (reversal adjunct) T1/2B
80 hours
163
Glycopyrrolate (reversal adjunct) Elimination
Hep/Renal
164
Glycopyrrolate (reversal adjunct) MoA
Anitmuscarinic
165
Neostigmine Vial
1mg/ml
166
Neostigmine Dose
0.02-0.07 mg/kg
167
Neostigmine Twitches dosing
2-3 twitches = 0.05 mg/kg, 4 twitches with fade= 0.04 mg/kg, 4 twitches with no fade = 0.015-0.025 mg/kg
168
Neostigmine Onset
1-5 min
169
Neostigmine Peak
5 min
170
Neostigmine Duration
60-120 min
171
Neostigmine T1/2B
60-120 min
172
Neostigmine Elmination
Hep/Plasma Cholinesterases
173
Neostigmine MoA
Anticholinesterase
174
Cisatracurium Vial
2 mg/ml
175
Cisatracurium Intub
0.1-0.2 mg/kg
176
Cisatracurium Maint
0.02 mg/kg
177
Cisatracurium Onset
2-3 min
178
Cisatracurium Peak
3-5 min
179
Cisatracurium Duration
30 min
180
Cisatracurium T1/2B
30 min
181
Cisatracurium Elimination
Hofmann
182
Cisatracurium MoA
Nicotinic M Antagonist (Nn, presynaptic)
183
Vecuronium Vial
1 mg/ml
184
Vecuronium intub
0.1 mg/kg
185
Vecuronium Maint
0.05 mg/kg
186
Vecuronium Onset
2-3 min
187
Vecuronium Peak
3-5 min
188
Vecuronium Duration
30 min
189
Vecuronium T1/2B
1-1.25 hours
190
Vecuronium Elimination
Renal/Hep
191
Vecuronium MoA
Nicotinic M Antagonist (Nn presynaptic)
192
Rocuronium Vial
10mg/ml
193
Rocuronium Intub
0.6-1.2 mg/kg (RSI=1.2 mg/kg)
194
Rocuronium Onset
60-120 secs (1 min RSI)
195
Rocuronium Peak
1-3 min (1 min RSI)
196
Rocuronium Duration
30-85 min
197
Rocuronium T1/2B
1.4 hours
198
Rocuronium Elimination
Renal/Hep
199
Rocuronium MoA
Nicotinic M Antagonist (Nn presynaptic)
200
Succinylcholine vial
20 mg/ml
201
Succinylcholine Intub
1 - 1.5 mg/kg (1.5 mg/kg with all defasciculation dose of NMB
202
Succinylcholine Onset
30-60 sec
203
Succinylcholine Peak
60 sec
204
Succinylcholine Duration
4-6 min
205
Succinylcholine T1/2B
1 min
206
Succinylcholine Defasciculate
Defasciculate with 10% ED95, usually we give 0.03 - 0.06 mg/kg of Roc; 3-5 min before intubating dose
207
Succinylcholine MoA
ACh agonist
208
Remifentanil vial
1 mg, 2mg, and 5 mg vials reconstitute powder in vial
209
Remifentanil Load Dose
0.5 - 1 mcg/kg/min or 1 mcg/kg over 30-60 seconds
210
Remifentanil Maint/hr
0.1-1.0 mcg/kg/min
211
Remifentanil Onset
1-2 min
212
Remifentanil Peak
3-6 min
213
Remifentanil Duration
3-10 mins
214
Remifentanil T1/2B
3- 10 mins
215
Remifentanil Elimination
nonspecific blood & tissue esterase
216
Remifentanil MoA
Mu opiod agonist
217
Morphine sulfate Vial
10 mg/ml
218
Morphine sulfate Load dose
2-10 mg/70 kg
219
Morphine sulfate Maint/Hr
0.1 - 0.2 mg/kg
220
Morphine sulfate Onset
5-14 min
221
Morphine sulfate peak
19 min
222
Morphine sulfate duration
2-4 hours
223
Morphine sulfate T1/2B
2 hours
224
Morphine sulfate Elimination
hep
225
Morphine sulfate MoA
Mu Opiod antagonist
226
Hydromorphone vial
1 mg/ml ; 2 mg/ml
227
Hydromorphone Load dose
0.5-2 mg
228
Hydromorphone Maint/Hr
n/a
229
Hydromorphone Onset
10-15 min
230
Hydromorphone Peak
10-20 min
231
Hydromorphone Duration
2-3 hours
232
Hydromorphone T1/2B
2-3 hours
233
Hydromorphone MoA
Hep
234
Hydromorphone Mix
dilute to 0.1 mg/ml
235
Morphine sulfate Mix
dilute to 1 mg/ml
236
Sufentanil vial
50 mcg/ml in 2 ml vial, dilute 100 mcg/8ml for 10 mcg/ml in 10 ml
237
Sufentanil Load dose
1-2 mcg/kg (case 1-2 hours), > 8 mcg/kg primary anesthetic
238
Sufentanil maint/hr
1 mcg/kg/hr of expected surgical time
239
Sufentanil Onset
immediate (1-3min)
240
Sufentanil Peak
2-3 min
241
Sufentanil Duration
30-60 min
242
Sufentanil T1/2B
2-3 hrs
243
Sufentanil Elimination
Hep
244
Sufentanil Mix
100mcg/8ml NS for 10 mcg/ml in 10 ml
245
Sufentanil MoA
Mu opiod agonist
246
Fentanyl Vial
50 mcg/ml
247
Fentanyl Load Dose
2-20 mcg/kg
248
Fentanyl Maint/Hr
1-2 mcg/kg
249
Fentanyl Onset
1-3 min
250
Fentanyl Peak
3-5 min
251
Fentanyl Duration
30-60 min
252
Fentanyl T1/2B
2-4 hours
253
Fentanyl Elimination
Hep/Pulm
254
Fentanyl MoA
Mu opiod agonist
255
Lidocaine (induction) dose
1-1.5 mg/kg
256
Lidocaine (induction) sedation
-
257
Lidocaine (induction) Onset
45-90 secs
258
Lidocaine (induction) Peak
1-2 min
259
Lidocaine (induction) Duration
10-20 min
260
Lidocaine (induction) T1/2B
1-2 hours
261
Lidocaine (induction) Elminination
Hep
262
Lidocaine (induction) MoA
Amide Na Channel Blocker
263
Dexmedotomidine vial
100 mcg/ml
264
Dexmedotomidine Dose
1 mcg/kg over 10 min
265
Dexmedotomidine sedation
0.2-0.7 mcg/kg/hr
266
Dexmedotomidine Onset
10-15 min
267
Dexmedotomidine Peak
infusion
268
Dexmedotomidine Duration
4 hours
269
Dexmedotomidine T1/2B
2 hours
270
Dexmedotomidine Elimination
Hep
271
Dexmedotomidine MoA
Alpha 2 Agonist
272
Midazolam vial
1 or 5 mg/ml
273
Midazolam dose
0.15-0.35 mg/kg
274
Midazolam Sedation
1-5 mg
275
Midazolam Onset
30-120 secs
276
Midazolam Peak
3-5 mins
277
Midazolam Duration
15-80 min
278
Midazolam T1/2B
1.5-3.5 hours
279
Midazolam Elimination
Hep
280
Midazolam MoA
BZ agonist on GABA
281
Ketamine vial
50 mg/ml
282
Ketamine dose
1-2 mg/kg
283
Ketamine sedation
0.2-0.8 mg/kg
284
Ketamine Onset
30-60 sec
285
Ketamine Peak
60 secs
286
Ketamine Duration
5-10 mins
287
Ketamine T1/2B
3 hours
288
Ketamine Elimination
Hep
289
Ketamine MoA
NMDA Antagonist
290
Etomidate vial
2mg/ml
291
Etomidate dose
0.2-0.3 mg/kg
292
Etomidate sedation
NO!!
293
Etomidate Onset
30-60 sec
294
Etomidate Peak
60 sec
295
Etomidate duration
4-8 mins
296
Etomidate T1/2B
3 hours
297
Etomidate Elimination
Hep
298
Etomidate MoA
GABA Agonist
299
Propofol vial
10mg/ml
300
Propofol dose
2-2.5 mg/kg
301
Propofol Sedation
25-75 mcg/kg/min
302
Propofol Onset
30-40 secs
303
Propofol peak
60 secs
304
Propofol duration
4-8 min
305
Propofol T1/2B
1-3 hours
306
Propofol Elimination
Hep/Pulm
307
Propofol MoA
GABA agonist
308
Bupivicaine Max dose Epi
3mg/kg
309
Lidocaine Duration Spinal
60-120 mins
310
lidocaine Max dose epi
7 mg/kg
311
Rocuronium Maint
0.15 mg/kg
312
Succinylcholine Elimination
plasma cholinesterase
