Drugs Flashcards
1
Q
Name some PPI
A
- omeprazole
- Lansoprazole
2
Q
Name the adverse effects of PPI
A
- increase risk of C. difficile infections
- hyponatraemia
- hypomagnasaemia
- osteoporosis
- microscopic colitis
3
Q
Name some H2 receptor antagonists
A
Ranitidine
4
Q
What does tranexamic acid do
A
- prevents plasmin from binding to and degrading fibrin
5
Q
What does terlipressin do
A
vasoconstrictor
6
Q
How does loperamide work
A
- Opioid receptor agonists
- decreases the activity of the myenteric plexus
- used in diarrhoea
7
Q
How does codeine phosphate work
A
- Opioid receptor agonists
- decreases the activity of the myenteric plexus (same as loperamide)
- used in diarrhoea
8
Q
Name some 5ASAs
A
- Mesalazine
- Sulphasalazine
9
Q
How do 5ASAs work
A
- Acts locally as an anti-inflammatory
- the mechanism of action is not fully understood but 5-ASA may inhibit prostaglandin synthesis
10
Q
What are the side effects of sulphasalazine
A
- rashes
- oligospermia
- headache
- heinz body anaemia
- megaloblastic anaemia
- lung fibrosis
11
Q
What are the side effects of mesalazine
A
- GI upset
- headache
- agranulocytosis
- pancreatitis
- interstitial nephritis
12
Q
What is the mechanism of action of azathioprine
A
- metabolised to the active compound mercaptopurine, a purine analogue that inhibits purine synthesis
13
Q
What are the adverse effects of azathioprine
A
- bone marrow depression
- nausea/vomiting
- pancreatitis
- increased risk of non-melanoma skin cancer
