Drugs

Question 1

Anti-thrombin 3

Answer 1

Is a naturally anti-coagulant in your body

indirect 2a and 10a inhibitor

Question 2

Fondaparinux

Answer 2

indirect 10a inhibitor
only SQ
used for prophylaxis

Question 3

Rivaroxaban and Apixaban

Answer 3

Direct Xa inhibitor
Oral
don’t use AT3

Antidote: is adaxanet Alpha

Question 4

Unfractionated/HMWH

Answer 4

only IV or SQ
must monitor labs
less risk of HIT
Reversed by protamine sulfate

Question 5

Anticoagulants

Answer 5

Bivalirudin

Argatroban

Dabigatran Etexilate Mesylate

Question 6

Warfarin

Answer 6

Is basically a competitive antagonist of Vitamin K epoxide reductase complex (VKORC1), blocks regeneration of reduced Vitamin K.

Warfarin’s effectiveness –> bleeding

Monitoring:INR

Question 7

Anti-platelet Drugs

Answer 7

Aspirin: irreversible COX inhibitor

Low dose aspirin is the easiest/ cheapest way to prevent thrombosis and stop stroke

Question 8

ADP receptor Inhibitors

Answer 8

Clopidogrel/prasugrel Irreversible ADP

Trigrelor: reversible ADP (P2Y) receptor antagonist

Glycoprotein 2b/3a inhibitors

Eptifibatide, Abciximab, Tirofiban

PDE inhibitors (dipyridamole)