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Addiction > Drug therapy > Flashcards

Drug therapy Flashcards

1
Q

What is the drug therapy for nicotine addiction?

A

Nicotinic replacement therapy

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2
Q

What is NRT?

A

Nicotinic replacement therapy

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3
Q

What is NRT?

A

An agonist substitution

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4
Q

What is the aim of NRT?

A

Provide nicotine from a less harmful source

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5
Q

What does NRT stimulate?

A

The nicotine receptors

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6
Q

What do the nicotine receptors activate?

A

The brains reward pathway

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7
Q

What does activation of the reward pathway release?

A

Dopamine down the limbic system

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8
Q

What does dopamine down the limbic stimulus stimulate?

A

The nucleus accumbens

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9
Q

What does stimulating the nucleus accumbens create?

A

Same euphoric feeling as smoking

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10
Q

What does NRT lead to a reduction in?

A

Withdrawal symptoms and stops cravings

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11
Q

What kind of reinforcement does NRT reduce?

A

Negative, removes unpleasant consequences of quitting smoking

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12
Q

What does NRT desensitise?

A

The nicotine receptors

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13
Q

How does NRT desensitise the nicotine receptors?

A

Releasing small amounts of nicotine so only some receptors are full of nicotine, not all

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14
Q

the number of nicotinic receptors ? over time with NRT

A

reduce

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15
Q

What can the addict do when their tolerance to nicotine has a reduced?

A

Gradually reduce the dose of nicotine

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16
Q

Name a drug being researched to treat gambling addiction?

A

naltrexone

17
Q

What is naltrexone?

A

Opiod antagonist

18
Q

What has naltrexone been conventionally used to treat?

A

Heroin addiction

19
Q

Why is a treatment for heroin addiction used for those with a gambling addiction?

A

There are similarities between gambling addictions and substance addictions

20
Q

What is the aim of opioid antagonist?

A

Reduce the pleasurable feeling associated with gambling

21
Q

What do opioid antagonists enhance?

A

The release of the neurotransmitter GABA

22
Q

Where is GABA released?

A

The mesolimbic pathway

23
Q

What does increased GABA activity reduce?

A

The release of dopamine in the nucleus accumbens and dopamine pre-frontal cortex

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