Drug Targets

Question 1

Inhibits dihydropteroate synthase
paba to folic acid

Answer 1

Sulfonamides

Question 2

Inhibits dihydrofolate reductase (DHFR)
DIHYDROFOLATE (DHF) to TETRAHYDROFOLATE (THF)

Answer 2

Trimethoprim

Question 3

From dUMP to dTMP to synthesize DNA
Inhibits the ENZYME (dna gyrase, topoisomerase Ii) that unwinds the DNA during replication

Answer 3

Quinolones

Question 4

inhibits bacterial RNA polymerase, preventing the synthesis of RNA from DNA.

Answer 4

Rifampicin

Question 5

By binding to the 50S subunit,____________ inhibit the formation of the initiation complex between the mRNA, tRNA, and the ribosome. This prevents the first step of protein synthesis from occurring and ultimately disrupts bacterial cell growth.

Answer 5

Oxazolidinones (linezolid)

Question 6

Inhibits 50s ribosome

Answer 6

Macrolides, clindamycin,

Question 7

Inhibits 30s ribosome

Answer 7

Aminoglycosides
Tetracyclines

Question 8

inhibits bacterial cell wall synthesis by interfering with the function of bactoprenol, a lipid carrier involved in transporting peptidoglycan precursors across the bacterial membrane.

Answer 8

Bacitracin

Question 9

inhibit the synthesis of peptidoglycan, a key component of the bacterial cell wall. They do this by binding to and inhibiting penicillin-binding proteins (PBPs), which are enzymes involved in the final stages of cell wall synthesis, including cross-linking the peptidoglycan strands.
Without the proper cross-linking, the cell wall becomes weak, leading to cell lysis and bactericidal effects.

Answer 9

Penicillins, cephalosporins