Drug Side Effects & CIs Flashcards
NSAIDs (Aspirin, Diclofenac, Ibuprofen)
Gastritis
Bronchospasm
Hypersensitivity
CI:
Ulcer/bleeding
NSAID-induced asthma
Coagulopathy
Avoid in children
Paracetamol
Avoid in hepatic inpairment
Opiates (codeins, meptazinol, oxycodone, pethidine, tramadol, morphine)
Nausea & vomiting Constipation Drowsiness Hypotension Resp depression Dependence
CI:
Acute resp depression
Acute alcoholism
Use with caution in head injury (affect neuro assessment)
Metoclopramide
Extrapyramidal SE
Antihistamines (chlorphenamine, cetirizine, levocetirizine, fenofexadine, loratadine)
Drowsiness Urinary retention Dry mouth Blurred vision GI disturbances Arrhythmias
H2 blockers (cimetidine, ranitidine)
GI disturbance
Raised LFTs
May mask symptoms of gastric ca
PPIs (omeprazole, lansoprazole, pantoprazole)
GI disturbance
Hypersensitivity
May mask symptoms of gastric ca
Heparins
Bleeding Thrombocytopenia Hypersensitivity Hyperkalaemia Osteoporosis (prolonged use)
CI: Coagulopathy Peptic ulcer Recurrent cerebral bleed Recent trauma/surgery Active bleeding
Temazepam
Drowsiness
Dependence
Zopiclone
Drowsiness
Dependence
Bitter taste
GI disturbances
Haloperidol
Extrapyramidal effects Sedation Hypotension Anti-muscarinic effects Meuroleptic malignant syndrome
Naloxone
Tachycardia
Fibrillation
Flumazenil
Convulsions
N&V
Flushing
Co-amoxiclav
May contribute to C.Diff infection
Gentamicin
Oto & nephro-toxicity