drug side effects

Question 1

anthracycline
- drug side effect
- common use

Answer 1

• irrev cardiomyopathy, secondary leukemias
• breast cancer, lymphoma

Question 2

antimetabolite ( 5 FU, capecitabine) side effect

Answer 2

Diarrhea, mucositis, hand-foot syndrome, coronary vasospasm

Question 3

antimetabolite usage ?

Answer 3

colon Ca
breast cancder

Question 4

topoisomerase inhib ( irinotecan, etoposide)
- SE ?

Answer 4

myelosuppression, diarrhea, nausea, vomiting, cholinergic reactions (Irinotecan)
Etoposide: Hypersensitivity reactions

Question 5

topoisomerase inhibitor usage ?

Answer 5

colon cancer
testicular cancer
lungs ( small cells)

Question 6

platinumd ( cisplatin/carboplatin/oxaliplatin)
- SE

Answer 6

All
– Peripheral neuropathy
Cisplatin-specific
– Highly emetogenic, nephrotoxic, ototoxic, hypoMg/Ca/K
Oxaliplatin-specific – Cold-induced neuropathy

Question 7

what does cisplastin cause specifically

Answer 7

• Highly emetogenic, nephrotoxic, ototoxic, hypoMg/Ca/K

Question 8

what does oxaliplatin cause specifically ?

Answer 8

cold induced neuropathy

Question 9

cisplatin used in ?

Answer 9

Cisplatin – Lung CA, H & N

Question 10

carboplatin used in ?

Answer 10

ovarian cancer

Question 11

oxaliplatin used in ?

Answer 11

colon ca

Question 12

taxanes ( paclitaxel, docetaxel)
- SE ?

Answer 12

Peripheral neuropathy, myalgias, hypersensitivity reaction (SOB, flushing, hypotension), fluid retention (docetaxel)

Question 13

taxanes used in which cancer?

Answer 13

breast cancer
ovarian cancer
prostate

Question 14

vinca alkaloids (vincristine, vinorelbine)
- side effect

Answer 14

peripheral neuuropathy

Question 15

vinca alkaloids ( vincristine, vinorelbine) used in what ?

Answer 15

Lung Ca
Breast Ca

Question 16

Cyclophosphamide **
- side effect

Answer 16

Emetogenic
Hemorrhagic cystitis, bladder CA
Secondary malignancies (MDS, AML, bladder Ca) Infertility

Question 17

one chemo that cause secondary malignancy such as mds, aml, blader cancer would be ?

Answer 17

cyclophosmide

Question 18

cyclophosphamide used for ?

Answer 18

breast cancer
connective tissue disease

Question 19

bleomycin causes what
-early vs delayed
- cummulative ?
- s&s
- imaging to dx

Answer 19

irreversible pneumonitis
- delayed
- cumulative
- pneumonitis sx ( fatigue, cough, SOB)
- ct chest

Question 20

how to dx heart toxic ity from anthracycline and trastuzumab ? and heart toxicity sx ?

Answer 20

HF picture
TTE to dx

Question 21

moderate to severe immunotherapy toxicity management

Answer 21

1. admit
2. steroids
3. infliximab if resistant
4. +/- empiric antibiotics

Question 22

c diff + ICI colitis ? tx ?

Answer 22

steroids + atb

Question 23

main component of immunotherapy management?

Answer 23

steroids !!!!

Question 24

severe nausea options

Answer 24

NK receptor antagonist ( neuprepitant, apreptant)
5tht3 ( ondazetron)
steroid ( dex)
5ht2-d2 antag ( olanzapine)

Question 25

NK1-receptor antagonist (-pitant) Ex. Neuprepitant, aprepitant used when ?

Answer 25

severe nausea

Question 26

anticipatory nausea medication?

Answer 26

lorazepam prn

Question 27

immunotherapy related myocarditis, what do you do as imaging ?

Answer 27

echocardiogram

Question 28

alopecia - types of drugs

Answer 28

- rubicin ( breast, lymphoma) - tecan ( lungs, gyne) - taxels ( lungs, gyne, breast)