BC and lung cancer Flashcards
post covid mammogram, how long should you wait ?
4-6 weeks
when do you move with surgery in breast cancer ?
once you localize the breast cancer
what stage of cancer do you do bone scan, CT C/A/P?
stage 3
pre menopausal women BC hormone tx
tamoxifene
post monopausal women with hormone + ?
Tamoxifen
aromatase inhibittor
hormonotherapy tx for BC
endocrine tx : tam/ai
cdk 4/6 : ciclibcs ( i.e. ribociclib)
her2 +
chemo - anthracycline
anti her2 - trastuzumab, pertuzumab
triple negative
chemo - anthracycline
immunotherapy ( i.e. pembrolizumab)
exercising 150 minutes per week in BC helps in what ?
reduce BC mortality
effects of tamoxifen ? ( side effect wise)
- increases risk of thrombosis and endometrial cancer
- decreases your risk of osteoporosis and cv risk
effects of aromatase inhibitor ( side effect wise)
- no effect on endometrial cancer and thrombosis
- increase risk of cv risk and osteoporosis
sided effect of anthracycline
irreversible cardiomyopathy that happesn later in the course ( even after finishing tx)
side effect of anti her2 ?
reversible cardiomyopathy during treatment ( early on)
which BC cancer causes irreversible cardiomyopathy
anthracyclin
which one : TAM vs AI to reduce CV risk?
TAM
4s of lung cancer
smokers get
squamous cell and
speedy
small cells
for neuroendocrine, which pet do you do ?
gallium PET
not a regular pet
carcinoid w/u in context of neuroendocrine ttumor
preop echo to r/o carcinoid heart
serum chromagranin A
urine 24hrs urine 5 HIAA
Gallium- PET scan
non small cell cancer and location if you can and link with cigarettes /mutations
- squamous cell : central , smokers , no mutations
- adenoCa : peripheral lesions , have mutations
- rare tumors
- neuroendocrne
-adenosquamous
- sarcomatoid
- large cells
small cell lung cancer pattern
- location
- mutation ?
- smoker ?
- growth ?
- central
- none
- yes
- rapidly growing ( speedy small cells )
what can you see as a pareneoplastic syndrome in SCLC ( and attb)
- SIADH
- lambert eaton ( anti vgcc ab) : reduces presynpatic ach release . very similar to myasthenia gravis
- encephalomyelitis and sensory neuropathy
* anti HU : cross reacts w/ both SCLC antigens and neuron-specific RNA-binding nuclear proteins - cushing’s syndrome : ectopic ACTTH production not suppresed by dexamethasone supp test
difference between lambert eaton vs myasthenia gravis
notably reduced/absent reflexes
hypertrophic osteoarthropathy
- what is it ?
- where
Clubbing+periosteal new bone formation of tubular bones
Symmetrical,painful arthropathy (ankles,knees,wrists,elbows)
hypertrophic osteoarthropathy can happen with ?
adeno
NSCLC
