Drug Side Effects

Question 1

Levodopa

Answer 1

Dyskinesia
On-off effect
Palpitations
Postural hypotension
Drowsiness
Psychosis
Anorexia
Less effective with time

Question 2

Rifampicin

Answer 2

Orange secretions
Thrombocytopenia
Nausea & vomiting
CYP inducer

Question 3

Isoniazid

Answer 3

Peripheral neuropathy (give pyridoxine (B6))
Hepatitis
Agranulocytosis
CYP inhibitor

Question 4

Pyrazinamide

Answer 4

Gout

Question 5

Ethambutamol

Answer 5

Visual impairment

Question 6

Methotrexate

Answer 6

Myelosuppression
Cirrhosis
Pneumonitis

Question 7

Sulfasalazine

Answer 7

Rash
Oligospermia
Heinz body anaemia
Interstitial lung disease
Insomnia
Stomatitis
Tinnitus
Facial oedema
Seizure
Vasculitis
Vertigo

Question 8

Leflunomide

Answer 8

Liver damage
Interstitial lung disease
Hypertension

Question 9

Hydroxychloroquine

Answer 9

Retinopathy
Corneal deposits

Question 10

Prednisolone

Answer 10

Cushing’s
Osteoporosis
Impaired glucose tolerance
Hypertension
Cataract

Question 11

Metformin

Answer 11

GI upset
Lactic acidosis

Question 12

Sulphonylureas

Answer 12

Hypoglycaemia
Increased appetite -> weight gain
SIADH
Cholestasis

Question 13

Glitazones

Answer 13

Fluid retention
Weight gain
Liver dysfunction
Fractures

Question 14

Gliptins

Answer 14

Pancreatitis

Question 15

Retinoids

Answer 15

Teratogenicity - females should use 2 forms of contraception
Dry skin/eyes/lips/mouth - most common
Low mood
Raised triglycerides
Hair thinning
Nose bleeds
Intracranial hypertension (do not give with TCAs)
Photosensitivity

Question 16

Thiazide diuretics (common)

Answer 16

Common:
Hypochloraemic alkalosis
Nausea
Constipation
Diarrhoea
Dizziness
Gout
Hyponatraemia
Hypokalaemia
Hypercalcaemia
Headache
Urticaria

Question 17

Thiazide diuretics (uncommon)

Answer 17

Uncommon:
Agranulocytosis
Aplastic anaemia
Leukopenia
Pancreatitis
Photosensitivity
Thrombocytopenia

Question 18

Ciclosporin

Answer 18

Gingival hyperplasia
Eye inflammation
Hyperglycaemia
Hyperlipidaemia
Hypertension
Gout
Gynaecomastia
Haemolytic anaemia
Intracranial hypertension
Leukopenia
Pancreatitis

Question 19

Phenytoin

Answer 19

Agranulocytosis
C+N+V
Confusion
Gingival hyperplasia
Hair changes
Headache
Movement disorders
Polyarteritis nodosa
Severe cutaneous adverse reaction
SLE
Vertigo

Question 20

Amiodarone

Answer 20

Thyroid dysfunction
Corneal deposits
Photosensitivity
Pulmonary fibrosis/pneumonitis
Liver fibrosis/hepatitis
Slate grey appearance
Peripheral neuropathy
Constipation
Altered taste
Bradycardia
Thrombophlebitis