Drug Short List

Question 1

Lispro

Answer 1

Quick, short acting insulin

Only give if pt about to eat

Question 2

Regular insulin

Answer 2

Short acting insulin
Gold standard for insulin
Usually given with NPH to mimic natural insulin levels

Question 3

NPH insulin

Answer 3

Intermediate release insulin
Acts as basal rate
Usually given with Regular Insulin

Question 4

Glargine

Answer 4

Long acting
No peak
Acts as very little amount secreted by pancreas thru the day

Question 5

Metformin

Answer 5

Diabetic adjunctive agent
Drug of choice for DM2
MOA: Inhibits liver’s glucose production, Insulin sensitizer
AEs: GI distress and lacticacidosis

DOES NOT INDUCE HYPOGLYCEMIA –> does not increase insulin in the blood

Question 6

Glipizide

Answer 6

Diabetic adjunctive agent
MOA: Requires working pancreas –> stimulates pancreas to release insulin
AEs: Hypoglycemia, do not give in preg

Question 7

Repaglinide

Answer 7

Diabetic adjunctive agent
MOA: stimulates pancreas to release insulin like Glipizide. If one doesn’t work, the other won’t either
AEs: RAPID hypoglycemia, rapid half life

Question 8

Sitagliptin

Answer 8

Diabetic adjunctive agent
MOA: Stimulates insulin production and suppresses glucagon release by inhibiting enzyme DPP-4
AEs: URI, H/A, inflammation of nasal passages and throat, hypoglycemia, pancreatitis

Question 9

Liraglutide

Answer 9

Diabetic adjunctive agent
MOA: Incretin mimetic –> Stimulates insulin production and suppresses glucagon release
AEs: GI distress, pancreatitis

• *Decreasse glipizide (sulfonyurea) dosing if used in conjunction with liraglutide**
• *Adminstered SQ!**

Question 10

Pioglitazone

Answer 10

Diabetic adjunctive agent
MOA: Inhibits liver’s glucose production, Insulin sensitizer
AEs: hypoglycemia, fluid retention, sinusitis and RTIs, CYP450

• *cannot be used as a solo agent**
• *Do not give to heart patients!**