Drug S.E.

Question 1

Atypical antipsychotics

Answer 1

Affect post synaptic D2
EPSE (less than typical)
Weight gain
Drowsiness
Sexual dysfunction
High prolactin
Arrythmias

Question 2

Lithium

Answer 2

Weight gain
Hypothyroidism
GI disturbance
Diabetes insipidus
Intention tremor
Idiopathic intracranial HTN
Flattening of T wave

Question 3

Olanzapine

Answer 3

Sedation and metabolic syndrome

Question 4

Quetiapine

Answer 4

Long QTc

Question 5

Risperidone

Answer 5

Metabolic derangement e.g. raised prolactin

Question 6

Clozapine

Answer 6

Affects D1 and 4 and 5HT
Same as atypical but less likelihood of EPSE so can give at higher dose
Hypersalivation and other cholinergic effects (e.g. constipation)
Agranulocytosis - leukopenia, eosinophilia, leucocytosis → regular blood tests for WCC to prevent

Question 7

Sodium Valproate Pregnancy

Answer 7

Neural Tube defect and dysmorphia

Question 8

Clozapine monitoring

Answer 8

Weekly blood tests for 18 weeks, fortnightly for 1 year then monthly indefinitely

Question 9

TCA

Answer 9

Dosulepin and amitriptyline most dangerous, so avoid giving to suicidal patients
Avoid in elderly as sensitive
Prolong QTc

Question 10

Benzodiazepine

Answer 10

Increase frequency

FREnzodiazepine

Question 11

Barbiturates

Answer 11

Increase duration

BarbitDURATes

Question 12

Taking Triptans

Answer 12

Avoid SSRI

Question 13

Venlafaxine

Answer 13

Avoid in HTN

Question 14

Taking Warfarin / Heparin

Answer 14

Mirtazapine

Question 15

Mirtazapine

Answer 15

Promotes weight gain and increases appetite

Question 16

Mirtazapine

Answer 16

Promotes weight gain and increases appetite

Question 17

SSRI

Answer 17

Drowsiness.
Nausea.
Dry mouth.
Insomnia.
Diarrhea.
Nervousness, agitation or restlessness.
Dizziness.
Sexual problems, such as reduced sexual desire or difficulty reaching orgasm or inability to maintain an erection (erectile dysfunction)