Drug Receptor Theory

Question 1

Drug receptor theory

Out of the internet

Answer 1

Receptor theory is essential to understanding drug action and states that drugs act as agonists, antagonists, or inverse agonists of physiologic receptors and thus can only mimic, intensify, inhibit, or block normal physiologic responses.

Question 2

Physiological receptors

Answer 2

Receptors that serve for the endogenous ligands for physiological functions

Question 3

Drug affinity measure

Answer 3

Dissociation constant [strength of the reversible interaction between a range it’s receptor. ]

Question 4

Agonists mimic physiological ligands

Answer 4

Primary agonist- primary r orthosteric site/ allosteric - different region/ block or reduce the action of agonist are antagonists [ allosteric, chemical,functional], partial agonists regard less of the concentration, inverse agonist.

Question 5

Inverse agonists

Answer 5

• Regulates the receptors that exhibit action despite the absenceof a ligand

Question 6

Receptor occupancy theory

Answer 6

Laws of mass action is the basis for the law of mass action

Question 7

Efficacy

Answer 7

The ability of a drug to activated receptor generate a cellular response is a reflection of its efficacy

Question 8

Historical quantification of efficacy

Answer 8

A proportionality constant that quantifies the extent of functional change impacted to a receptor-mediated response system on binding a drug

Question 9

Relative apparent dissociation constant

Answer 9

Kapp- a macroscopic equilibrium constant that reflects the ligand binding equilibrium and the subsequent equilibrium results formats in the on of the active receptor LR

Question 10

In viva (0) drug life-cycle

Answer 10

O- distribute to specific targets o receptor, 1-bind to receptor, 12. Promote/block- activation of receptor-mediated physiological effects. 4. Termination of effect.

Question 11

Receptors - functional mediators