drug receptor interactions Flashcards
which form of the drug is more water soluble?
dissociated unprotonated form
which form of the drug is more lipid soluble?
undissociated protonated form
how do you calculate volume of distribution?
amount of drug in the body divided by the plasma concentration of the drug
what does Vd show?
how well a drug is distributed around the body
what does a high Vd indicate?
small concentration in the blood. more is in the tissue. drug is more lipid soluble
what does a low Vd show?
high concentration in the blood. more is in the plasma. more water soluble.
what is drug distribution?
process by which drug reversibly leaves the blood stream and enters the extra cellular fluid
what are the major body compartments?
water
fat
solid
what is the water compartment made up of?
ICF
ECF (plasma and ISF)
what proportion of the body weight does the water compartment make up?
60%
what does the fat compartment consist of?
brain
adipose tissue
cell membranes
what does the solid compartment consist of?
bone
muscle
what is albumin?
a plasma protein that drugs can bind to
how does albumin help in the transport of drugs?
drugs bind to albumin once they’re released from the GI system and they’re carried in an inert form. protects drug from body’s metabolism
in what form can drugs bind to receptor?
in the free form
not bound to proteins