Drug/receptor interactions Flashcards
1
Q
Define intrinsic efficacy
A
The ability of a ligand to bind to a receptor and cause its activation
2
Q
How can the amount of drug-receptor interactions be measured?
A
Using radio ligands (radioactive versions of a ligand)
3
Q
Define efficacy
A
The ability of a ligand to carry out a response, upon binding
4
Q
What is binding determined by?
A
Association and dissociation
5
Q
What is Bmax?
A
Maximum binding capacity
6
Q
What is Kd?
A
Dissociation constant
7
Q
What is the advantage of having specific adrenoceptor agonists that only target specific sub-types?
A
Targeted & specific response, localise effects, limit side effects
