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Pharm III Unit 1 > Drug of Abuse > Flashcards

Drug of Abuse Flashcards

1
Q

Physiological dependence

A

neuroadaptations abnormal behavior and physical symptoms (withdrawal) occur if drug is withdrawn

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2
Q

Psychological dependence

A

dysphoria and intense craving following withdrawal of drug. Occurs with or without physical dependence

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3
Q

Withdrawal

A

Adverse reactions caused by discontinuation of drug; Based on physical neuroadaptations of brain; Release of dynorphin and GABA in the nucleus accumbens

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4
Q

Tolerance

A

More drug is required to produce effect.

Dose/response is shifted to the right.

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5
Q

Sensitization

A

Increase of responsiveness after

repeated use. Dose/response is shifted to the left.

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6
Q

Reward pathway

A

Mesolimbic dopamine pathway: VTA –> NAc –> Prefrontal cortex

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7
Q

Tx for alcohol addiction

A

Naltrexone, acamprosate, disulfiram, topiramate

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8
Q

Tx for opioid addiction

A

Methadone, buprenorphine, naltrexone, naloxone

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9
Q

Tx for nicotine addiction

A

Nicotine replacement therapy, bupropion, varenicline (combined w/ behavioral treatment)

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10
Q

Reverses dopamine transport through DAT (reuptake) → increased release of dopamine

A

amphetamine

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11
Q

Causes amphetamine psychosis

A

Methamphetamine

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12
Q

Chronic use of methamphetamine cause

A

permanent damgae to noradrenergic and serotonergic neurons; loss of DA transporters

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13
Q

Tx to decrease craving of cocaine

A

Bromocriptine

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14
Q

_________ during ecstacy and _______ after ectasy

A

Increase 5HT; Decreased 5HT

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15
Q

MDMA SE

A

Hyperthermia, dehydration, kidney failures

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16
Q

Drug with no physical dependence, but possible psych dependence (no up or down regulation)

A

Marijuana

17
Q

SE: Amotivational syndrome

A

Marijuana

18
Q

SE: Cannbinoid hyperemesis

A

Marijuana

19
Q

SE: Decreased ovluation and testosterone/ sperm production

A

Marijuana

20
Q

Synesthesia associated w/

A

LSD, mescaline, psilocybin

21
Q

drugs that does not cause dependence and does not stimulate DA pathway

A

LSD, mescaline, psilocybin

22
Q

Teen presented to the clinic with psychosis after taking too much angel dust because he wanted to become an angel. How do you treat this pt?

A

Haloperidol

23
Q

Date rape drugs

A

Ketamine and GHB

24
Q

Chronic use of NO causes

A

peripheral neuropathy

25
Q

Poppers or snappers

A

Amyl and butyl nitrate

26
Q

Angel dust

A

PCP

27
Q

SE: Fetal malformation, Low birth weight

A

Marijuana

28
Q

Overdose sxs of chronic cocaine use

A

Ventricular tachy and fib, stroke or cerebral hemorrhage, seizures

29
Q

Synthetic “cannabinoid” agonists

A

Marijuana

30
Q

SE: bronchial irritation, risk of cancer

A

Marijuana

Pharm III Unit 1 (9 decks)

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